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url url url url
  2. Weltenzyklopädie
  3. کلوپنتیکسول
کلوپنتیکسول
از ویکی‌پدیا، دانشنامهٔ آزاد
کلوپنتیکسول
داده‌های بالینی
روش مصرف داروخوراکی
کد ATC
شناسه‌ها
  • (E,Z)-2-[4-[3-(2-chlorothioxanthen-9-ylidene) propyl]piperazin-1-yl]ethanol
شمارهٔ سی‌ای‌اس
پاب‌کم CID
کم‌اسپایدر
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.012.333 ویرایش در ویکی‌داده
داده‌های فیزیکی و شیمیایی
فرمول شیمیاییC22H25ClN2OS
جرم مولی۴۰۰٫۹۷ g·mol−1
مدل سه بعدی (جی‌مول)
  • Clc2cc1C(c3c(Sc1cc2)cccc3)=CCCN4CCN(CCO)CC4
  (صحت‌سنجی)

کلوپنتیکسول(به انگلیسی: Clopenthixol) (با نام تجاری Sordinol) یک داروی ضد روان پریشی تیپیکال و از کلاس تیوکسانتن است. این دارو نخستین بار توسط شرکت لوندبک در سال ۱۹۶۱ معرفی شد.[۱]

کلوپنتیزکسول مخلوطی از ایزومرهای سیس و ترانس است. زوکلوپنتیکسول، ایزومر خالص سیس این دارو است که بعداً توسط لوندبک در سال ۱۹۶۲ معرفی شد[۲]و مورد استفاده بسیار گسترده تری قرار گرفت. خاصیت ضدروانپریشی هر دو دارو به یک اندازه است و از نظر عوارض جانبی نیز مشابه هم هستند، اما از نظر فعالیت دارویی تنها نیمی از جرم کلوپنتزیکسول فعال می‌باشد. همچنین کلوپنتزیکسول خاصیت آرام‌بخشی بیشتری ایجاد می‌کند.[۳]

کلوپنتیکسول برای استفاده در ایالات متحده تأیید نشده‌است.

جستارهای وابسته

[ویرایش]

منابع

[ویرایش]
  1. ↑ Sneader, Walter (2005). Drug discovery: a history. New York: Wiley. p. 410. ISBN 0-471-89980-1.
  2. ↑ José Miguel Vela; Helmut Buschmann; Jörg Holenz; Antonio Párraga; Antoni Torrens (2007). Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application. Weinheim: Wiley-VCH. p. 516. ISBN 978-3-527-31058-6.[پیوند مرده]
  3. ↑ Gravem A, Engstrand E, Guleng RJ (November 1978). "Cis(Z)-clopenthixol and clopenthixol (Sordinol) in chronic psychotic patients. A double-blind clinical investigation". Acta Psychiatr Scand. 58 (5): 384–8. doi:10.1111/j.1600-0447.1978.tb03570.x. PMID 362830.

پیوند به بیرون

[ویرایش]
برگرفته از «https://fa.wikipedia.org/w/index.php?title=کلوپنتیکسول&oldid=40429166»
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