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url url url url
  2. Weltenzyklopädie
  3. ام‌ام‌دی‌ای (دارو) - ویکی‌پدیا، دانشنامهٔ آزاد
ام‌ام‌دی‌ای (دارو) - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد
ام‌ام‌دی‌ای
داده‌های بالینی
روش مصرف داروخوراکی، دمیدن، راست‌روده
کد ATC
  • None
وضعیت قانونی
وضعیت قانونی
شناسه‌ها
  • 1-(7-Methoxy-1,3-benzodioxol-5-yl)propan-2-amine
شمارهٔ سی‌ای‌اس
پاب‌کم CID
کم‌اسپایدر
UNII
CompTox Dashboard (EPA)
داده‌های فیزیکی و شیمیایی
فرمول شیمیاییC11H15NO3
جرم مولی۲۰۹٫۲۴۵ g·mol−1
مدل سه بعدی (جی‌مول)
  • O1c2cc(cc(OC)c2OC1)CC(N)C

ام‌ام‌دی‌ای(مخفف انگلیسی: MMDA) یک داروی روانگردان و آنتاکتوژن از کلاس آمفتامین است؛ که آنالوگ ساختاری لوفوفین، MDA و MDMA به حساب می‌آید.

الکساندر شولگین در کتاب PiHKAL دامنه دوز MMDA را ۱۰۰ تا ۲۵۰ میلی‌گرم ذکر کرده‌است. اولین اثرات در طی ۳۰–۶۰ دقیقه پس از مصرف خوراکی ظاهر می‌شود. MMDA باعث ایجاد سرخوشی و گرمای دوست داشتنی می‌شود و احساساتی مانند اضطراب و تنهایی را کاهش می‌دهد. همچنین باعث ایجاد توهم با چشم‌های بسته، خواب‌آلودگی، شل شدن عضلات و اختلال در درک زمان می‌شود. عوارض جانبی شامل گشادی مردمک چشم، سرگیجه، احساس گرما یا سرما و لرزش است. توهمات بصری ناشی از MDMA معمولاً واقع‌گرایانه و مربوط به ادراک روزمره است. اوج اثرات این ماده معمولاً در اولین ساعت مصرف و پس از اثرات اولیه است. در ساعت دوم شروع به کاهش می‌کند و معمولاً در پایان ساعت پنجم کاملاً از بین می‌رود.

اقدامات روان درمانی

کلودیو نارنجو در کتاب سفر شفا، کاربردهای بالقوه‌ای برای MDMA از جمله آسان‌تر شدن ارتباط را پیشنهاد داد.

داروشناسی

MMDA به عنوان یک ماده آزاد کننده سروتونین غیر عصبی و به عنوان یک آگونیست گیرنده 5-HT2A[۱] عمل می‌کند[۲] و هیچ تأثیری در ترشح دوپامین و احتمالاً ترشح نوراپی نفرین نیز ندارد. خاصیت دوم مسئول اثرات روانگردان و مورد اول مسول اثرات روحیه بخشی و امفاتوژن آن است.

منابع

  1. ↑ Zhang Z, An L, Hu W, Xiang Y (April 2007). "3D-QSAR study of hallucinogenic phenylalkylamines by using CoMFA approach". Journal of Computer-aided Molecular Design. 21 (4): 145–53. doi:10.1007/s10822-006-9090-y. PMID 17203365.
  2. ↑ McKenna DJ, Guan XM, Shulgin AT (March 1991). "3,4-Methylenedioxyamphetamine (MDA) analogues exhibit differential effects on synaptosomal release of 3H-dopamine and 3H-5-hydroxytryptamine". Pharmacology Biochemistry and Behavior. 38 (3): 505–12. doi:10.1016/0091-3057(91)90005-M. PMID 1829838.
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