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url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url 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url url
  2. Weltenzyklopädie
  3. ای‌آر-ای۰۰۰۰۰۲ - ویکی‌پدیا، دانشنامهٔ آزاد
ای‌آر-ای۰۰۰۰۰۲ - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد
ای‌آر-ای۰۰۰۰۰۲
داده‌های بالینی
کد ATC
  • None
شناسه‌ها
  • (R)-N-[5-methyl-8-(4-methylpiperazin-1-yl)-1,2,3,4-tetrahydro-2-naphthyl]-4-morpholinobenzamide
پاب‌کم CID
کم‌اسپایدر
CompTox Dashboard (EPA)
داده‌های فیزیکی و شیمیایی
فرمول شیمیاییC27H36N4O2
جرم مولی۴۴۸٫۶۱۱ g·mol−1
مدل سه بعدی (جی‌مول)
  • C5COCCN5c(cc4)ccc4C(=O)NC2CCc1c(C2)c(ccc1C)N3CCN(C)CC3
  • InChI=1S/C27H36N4O2/c1-20-3-10-26(31-13-11-29(2)12-14-31)25-19-22(6-9-24(20)25)28-27(32)21-4-7-23(8-5-21)30-15-17-33-18-16-30/h3-5,7-8,10,22H,6,9,11-19H2,1-2H3,(H,28,32)/t22-/m1/s1
  • Key:IHDRUIHIJWCTIY-JOCHJYFZSA-N
  (صحت‌سنجی)

ای‌آر-ای۰۰۰۰۰۲ (انگلیسی: AR-A000002) یک داروی آنتاگونیست گیرنده ۱ بی سروتونین است[۱] که بیش از ۱۰ برابر بیشتر گیرنده ۱ دی سروتونین برای 5-HT1B انتخابی است.[۲] این دارو سبب افزایش پایدار سطح سروتونین در مغز شده و در مدل‌های حیوانی، خواص ضداضطراب داشته‌است.[۳][۴]

منابع

  1. ↑ Hudzik TJ, Yanek M, Porrey T, Evenden J, Paronis C, Mastrangelo M, et al. (March 2003). "Behavioral pharmacology of AR-A000002, a novel, selective 5-hydroxytryptamine(1B) antagonist". The Journal of Pharmacology and Experimental Therapeutics. 304 (3): 1072–84. doi:10.1124/jpet.102.045468. PMID 12604684.
  2. ↑ Ahlgren C, Eriksson A, Tellefors P, Ross SB, Stenfors C, Malmberg A (September 2004). "In vitro characterization of AR-A000002, a novel 5-hydroxytryptamine(1B) autoreceptor antagonist". European Journal of Pharmacology. 499 (1–2): 67–75. doi:10.1016/j.ejphar.2004.07.067. PMID 15363952.
  3. ↑ Stenfors C, Ahlgren C, Yu H, Wedén M, Larsson LG, Ross SB (March 2004). "Effects of long-term administration of the 5-hydroxytryptamine1B receptor antagonist AR-A000002 to guinea pigs". Psychopharmacology. 172 (3): 333–40. doi:10.1007/s00213-003-1667-8. PMID 14652708.
  4. ↑ Stenfors C, Hallerbäck T, Larsson LG, Wallsten C, Ross SB (March 2004). "Pharmacology of a novel selective 5-hydroxytryptamine1B receptor antagonist, AR-A000002". Naunyn-Schmiedeberg's Archives of Pharmacology. 369 (3): 330–7. doi:10.1007/s00210-004-0866-0. PMID 14758468.
آیکون خرد

این یک مقالهٔ خرد پیرامون دارو یا داروشناسی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

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