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url url url url
  2. Weltenzyklopädie
  3. بنپریدول - ویکی‌پدیا، دانشنامهٔ آزاد
بنپریدول - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد
بنپریدول
Skeletal formula of benperidol
Ball-and-stick model of the benperidol molecule
داده‌های بالینی
نام‌های تجاریAnquil, Frenactil
AHFS/Drugs.comInternational Drug Names
روش مصرف داروخوراکی
کد ATC
وضعیت قانونی
وضعیت قانونی
شناسه‌ها
  • 1-{1-[4-(4-fluorophenyl)-4-oxobutyl]piperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one
شمارهٔ سی‌ای‌اس
پاب‌کم CID
کم‌اسپایدر
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.016.521 ویرایش در ویکی‌داده
داده‌های فیزیکی و شیمیایی
فرمول شیمیاییC22H۲۴FN۳O۲
جرم مولی۳۸۱٫۴۵۱ g·mol−1
مدل سه بعدی (جی‌مول)
  • Fc1ccc(cc1)C(=O)CCCN4CCC(N3c2ccccc2NC3=O)CC4
  • InChI=1S/C22H24FN3O2/c23-17-9-7-16(8-10-17)21(27)6-3-13-25-14-11-18(12-15-25)26-20-5-2-1-4-19(20)24-22(26)28/h1-2,4-5,7-10,18H,3,6,11-15H2,(H,۲۴٬۲۸) ✔Y
  • Key:FEBOTPHFXYHVPL-UHFFFAOYSA-N ✔Y
 N✔Y (این چیست؟)  (صحت‌سنجی)

بنپریدول (انگلیسی: Benperidol) که با نام تجاری Anquil[۱] فروخته می‌شود، دارویی است که مشتق بوتیروفنون بسیار قوی است. این داروی قوی‌ترین داروی اعصاب در بازار اروپا است معادل با کلرپرومازین تا ۷۵ تا ۱۰۰ (از نظر دوز در مقایسه با هالوپریدول)[۲] حدود ۱۵۰ تا ۲۰۰ درصد قدرت). این دارو یک داروی ضدروان‌پریشی است که می‌تواند برای درمان اسکیزوفرنی به کار رود،[۳] اما در درجه نخست برای کنترل سندرم‌های بیش‌فعالی جنسی به کار می‌رود.[۴] و گاهی برای مجرمان جنسی به عنوان شرط مشروط تجویز می‌شود، به عنوان جایگزینی برای داروهای ضد آندروژن مانند سیپروترون استات.[۵]

سنتز

سنتز بنپریدول:[۶]

جستارهای وابسته

منابع

  1. ↑ Council A, Kuenssberg V (1974-02-01). "Benperidol - a drug for sexual offenders?". Drug and Therapeutics Bulletin. BMJ Publishing Group Ltd. 12: 12.
  2. ↑ Möller HJ, Müller WE, Bandelow (2001). Neuroleptika: pharmakologische Grundlagen, klinisches Wissen und therapeutisches Vorgehen; mit 136 Tabellen (به آلمانی). Wiss. Verlag-Ges. ISBN 3-8047-1773-X.
  3. ↑ Bobon J, Collard J, Lecoq R (October 1963). "[Benperidol and promazine: a "double blind" comparative study in mental geriatrics]". Acta Neurologica Et Psychiatrica Belgica (به فرانسوی). 63: 839–43. PMID 14092279.
  4. ↑ British National Formulary (49th), British Medical Association 2005 p 183
  5. ↑ Murray MA, Bancroft JH, Anderson DC, Tennent TG, Carr PJ (November 1975). "Endocrine changes in male sexual deviants after treatment with anti-androgens, oestrogens or tranquillizers". The Journal of Endocrinology. 67 (2): 179–88. doi:10.1677/joe.0.0670179. PMID 1107462.
  6. ↑ BE 626307  (1963 to Janssen), C.A. 60, 10690c (1964), corresp. to GB 989755 .
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