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url url url url
  2. Weltenzyklopädie
  3. بیسولپین - ویکی‌پدیا، دانشنامهٔ آزاد
بیسولپین - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد
بیسولپین
داده‌های بالینی
کد ATC
شناسه‌ها
  • (3E)-N,N-dimethyl-3-(thieno[2,3-c][2]benzothiepin-4(9H)-ylidene)propan-1-amine
شمارهٔ سی‌ای‌اس
پاب‌کم CID
کم‌اسپایدر
UNII
ChEBI
CompTox Dashboard (EPA)
ECHA InfoCard100.024.867 ویرایش در ویکی‌داده
داده‌های فیزیکی و شیمیایی
فرمول شیمیاییC17H19NS۲
جرم مولی۳۰۱٫۴۷ g·mol−1
مدل سه بعدی (جی‌مول)
  • CN(C)CC\C=C1\c2ccsc2SCc2ccccc12

بیسولپین (به انگلیسی: Bisulepin) یک آنتی‌هیستامین قوی و نسبتاً انتخابی (آنتاگونیست H۱) با اثرات خواب‌آوری، آنتی‌آدرنرژیک و آنتی‌کولینرژیک و آنتی‌سروتونرژیک بسیار ضعیف است. بیسولپین در جمهوری چک و اسلواکی با نام تجاری Dithiaden به صورت قرص و تزریقی به بازار عرضه می‌شود.

فرم فعال ثبت شده این دارو، ایزومر trans- (یعنی E-) است.[۱][۲]

همچنین ببینید

منابع

  1. ↑ Polívka Z, Rajšner M, Metyš J, Holubek J, Svátek E, Ryska M, Protiva M (1983). "Antiaminic agents derived from thieno[2,3-c]-2-benzothiepin: 4-(1-Methyl-4-piperidylidene)-4,9-dihydrothieno[2,3-c]-2-benzothiepin and some related compounds". Collection of Czechoslovak Chemical Communications. 48 (2): 623–641. doi:10.1135/cccc19830623.
  2. ↑ Pharmacopoea Bohemoslovenica 4 (1987), vol. 2, p. 132 states that Bisulepinium chloratum (bisulepinium chloride) is trans-[3-(4,9-dihydro-thieno[2,3-c][2]benzithiepin-4-yliden)propyl]dimethylamoniumchlorid (Czech). The cis- isomer is considered as an impurity, max. amount 2.0 %.

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