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url url
  2. Weltenzyklopädie
  3. نیفلومیک اسید - ویکی‌پدیا، دانشنامهٔ آزاد
نیفلومیک اسید - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد
نیفلومیک اسید
داده‌های بالینی
AHFS/Drugs.comInternational Drug Names
کد ATC
داده‌های فارماکوکینتیک
نیمه‌عمر حذف۲٫۵ ساعت[۱]
شناسه‌ها
  • 2-{[3-(trifluoromethyl)phenyl]amino}nicotinic acid
شمارهٔ سی‌ای‌اس
پاب‌کم CID
IUPHAR/BPS
کم‌اسپایدر
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.022.289 ویرایش در ویکی‌داده
داده‌های فیزیکی و شیمیایی
فرمول شیمیاییC13H9F3N2O۲
جرم مولی۲۸۲٫۲۲۲ g·mol−1
مدل سه بعدی (جی‌مول)
نقطه ذوب۲۰۴ درجه سلسیوس (۳۹۹ درجه فارنهایت)
  • C1=CC(=CC(=C1)NC2=C(C=CC=N2)C(=O)O)C(F)(F)F
  • InChI=1S/C13H9F3N2O2/c14-13(15,16)8-3-1-4-9(7-8)18-11-10(12(19)20)5-2-6-17-11/h1-7H,(H,17,18)(H,۱۹٬۲۰) N
  • Key:JZFPYUNJRRFVQU-UHFFFAOYSA-N N
 N✔Y (این چیست؟)  (صحت‌سنجی)

نیفلومیک اسید (انگلیسی: Niflumic acid) دارویی است که برای درد مفاصل و عضلانی به کار می‌رود. به عنوان یک مهارکننده سیکلواکسیژناز-۲ طبقه بندی می‌شود. در زیست‌شناسی تجربی، از آن برای مهار کانال‌های کلرید استفاده شده‌است.[۲] همچنین گزارش شده‌است که روی کانال‌های GABA-A[۳] و NMDA[۴] عمل می‌کند و کانال‌های کلسیم نوع T را مسدود می‌کند.[۵]

منابع

  1. ↑ "Half life". Drug Bank. Retrieved 15 July 2011.
  2. ↑ Knauf PA, Mann NA (May 1984). "Use of niflumic acid to determine the nature of the asymmetry of the human erythrocyte anion exchange system". The Journal of General Physiology. 83 (5): 703–25. doi:10.1085/jgp.83.5.703. PMC 2215658. PMID 6736917.
  3. ↑ Sinkkonen ST, Mansikkamäki S, Möykkynen T, Lüddens H, Uusi-Oukari M, Korpi ER (September 2003). "Receptor subtype-dependent positive and negative modulation of GABA(A) receptor function by niflumic acid, a nonsteroidal anti-inflammatory drug". Molecular Pharmacology. 64 (3): 753–63. doi:10.1124/mol.64.3.753. PMID 12920213.
  4. ↑ Lerma J, Martín del Río R (February 1992). "Chloride transport blockers prevent N-methyl-D-aspartate receptor-channel complex activation". Molecular Pharmacology. 41 (2): 217–22. PMID 1371581.
  5. ↑ Balderas E, Ateaga-Tlecuitl R, Rivera M, Gomora JC, Darszon A (June 2012). "Niflumic acid blocks native and recombinant T-type channels". Journal of Cellular Physiology. 227 (6): 2542–55. doi:10.1002/jcp.22992. PMC 4146346. PMID 21898399.
آیکون خرد

این یک مقالهٔ خرد داروشناسی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

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