Lifestyle Khazanah Profil Baru Dram Lists Ensiklopedia
Technopedia Center
PMB University Brochure
Faculty of Engineering and Computer Science
S1 Informatics S1 Information Systems S1 Information Technology S1 Computer Engineering S1 Electrical Engineering S1 Civil Engineering

faculty of Economics and Business
S1 Management S1 Accountancy

Faculty of Letters and Educational Sciences
S1 English literature S1 English language education S1 Mathematics education S1 Sports Education
teknopedia

teknopedia

teknopedia

teknopedia

teknopedia

teknopedia
teknopedia
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teknopedia
teknopedia
url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url 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url url
  2. Weltenzyklopädie
  3. تنیداپ - ویکی‌پدیا، دانشنامهٔ آزاد
تنیداپ - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد
تنیداپ
داده‌های بالینی
کد ATC
شناسه‌ها
  • 5-chloro-2-hydroxy-3-(2-thienylcarbonyl)-1H-indole-1-carboxamide
شمارهٔ سی‌ای‌اس
پاب‌کم CID
کم‌اسپایدر
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
داده‌های فیزیکی و شیمیایی
فرمول شیمیاییC14H9ClN2O3S
جرم مولی۳۲۰٫۷۵ g·mol−1
مدل سه بعدی (جی‌مول)
  • c1cc(sc1)C(=O)c2c3cc(ccc3n(c2O)C(=O)N)Cl
  • InChI=1S/C14H9ClN2O3S/c15-7-3-4-9-8(6-7)11(13(19)17(9)14(16)20)12(18)10-2-1-5-21-10/h1-6,19H,(H2,16,20) N
  • Key:IZSFDUMVCVVWKW-UHFFFAOYSA-N N
 N✔Y (این چیست؟)  (صحت‌سنجی)

تنیداپ (انگلیسی: Tenidap) یک مهار کننده COX/5-LOX و داروی ضدالتهابی تعدیل‌کننده سیتوکین بود که توسط شرکت فایزر به عنوان یک درمان بالقوه امیدوارکننده برای روماتیسم مفصلی در حال توسعه بود،[۱][۲] اما فایزر توسعه را متوقف کرد پس از تأیید بازاریابی توسط FDA در سال ۱۹۹۶ به دلیل آسیب به کبد و مسمومیت کلیه، که به متابولیت‌های دارو با یک گروه تیوفن نسبت داده می‌شود که باعث آسیب اکسیداتیو می‌شود.[۳][۴]

منابع

  1. ↑ Wylie G, Appelboom T, Bolten W, Breedveld FC, Feely J, Leeming MR, et al. (June 1995). "A comparative study of tenidap, a cytokine-modulating anti-rheumatic drug, and diclofenac in rheumatoid arthritis: a 24-week analysis of a 1-year clinical trial". British Journal of Rheumatology. 34 (6): 554–63. doi:10.1093/rheumatology/34.6.554. PMID 7543348.
  2. ↑ Staff, American Journal of Nursing. Drug Watch: Tenidap Offers Arthritis Therapy Minus Toxicity AJN 1996 96(1):58
  3. ↑ Pfizer. Sept 27, 1996 Press release: Pfizer To Halt Plans For Commercialization Of Tenidap For Rheumatoid Arthritis بایگانی‌شده در ۵ مارس ۲۰۱۶ توسط Wayback Machine
  4. ↑ Hwang SH, Wecksler AT, Wagner K, Hammock BD (2013). "Rationally designed multitarget agents against inflammation and pain". Current Medicinal Chemistry. 20 (13): 1783–99. doi:10.2174/0929867311320130013. PMC 4113248. PMID 23410172.
آیکون خرد

این یک مقالهٔ خرد داروشناسی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

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