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faculty of Economics and Business
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Faculty of Letters and Educational Sciences
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teknopedia

teknopedia

teknopedia

teknopedia

teknopedia

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teknopedia
url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url url 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url url
  2. Weltenzyklopädie
  3. سیمیکوکسیب - ویکی‌پدیا، دانشنامهٔ آزاد
سیمیکوکسیب - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد
سیمیکوکسیب
نام آیوپاک ارجح

4-[4-Chloro-5-(3-fluoro-4-methoxyphenyl)-1H-imidazol-1-yl]benzene-1-sulfonamide

شناساگرها
شماره ثبت سی‌ای‌اس ۲۶۵۱۱۴-۲۳-۶ ✔Y
پاب‌کم ۲۱۳۰۵۳
کم‌اسپایدر ۱۸۴۷۴۵
ChEBI CHEBI:76127
ChEMBL CHEMBL۴۳۵۳۸۱
جی‌مول-تصاویر سه بعدی Image 1

  • O=S(=O)(c3ccc(n1c(c(Cl)nc1)c2ccc(OC)c(F)c2)cc3)N

  • InChI=1S/C16H13ClFN3O3S/c1-24-14-7-2-10(8-13(14)18)15-16(17)20-9-21(15)11-3-5-12(6-4-11)25(19,22)23/h2-9H,1H3,(H2,۱۹٬۲۲٬۲۳)
    Key: KYXDNECMRLFQMZ-UHFFFAOYSA-N

    InChI=1/C16H13ClFN3O3S/c1-24-14-7-2-10(8-13(14)18)15-16(17)20-9-21(15)11-3-5-12(6-4-11)25(19,22)23/h2-9H,1H3,(H2,۱۹٬۲۲٬۲۳)
    Key: KYXDNECMRLFQMZ-UHFFFAOYAQ

خصوصیات
فرمول مولکولی C16H13ClFN3O3S۱
جرم مولی ۳۸۱٫۸۱ g mol−1
به استثنای جایی که اشاره شده‌است در غیر این صورت، داده‌ها برای مواد به وضعیت استانداردشان داده شده‌اند (در 25 °C (۷۷ °F)، ۱۰۰ kPa)
Infobox references


سیمیکوکسیب (UR-8880 با نام تجاری Cimalgex) یک داروی ضدالتهاب غیراستروئیدی (NSAID) است که در دامپزشکی برای درمان درد و التهاب مرتبط با آرتروز در سگ‌ها و برای مدیریت درد و التهاب مرتبط با جراحی استفاده می‌شود.[۱] این دارو به عنوان یک مهارکننده کوکس-۲ عمل می‌کند.

سنتز

سنتز سیمیکوکسیب:[۲]

واکنش ایمین با TosMIC در حضور پتاسیم کربنات منجر به به حلقه‌زایی ۲+۳ از آنالوگِ نیتروژنِ کتن و تشکیل حلقه ایمیدازول می‌شود.

منابع

  1. ↑ "European Public Assessment Report: Cimalgex (cimicoxib)". European Medicines Agency. Archived from the original on 15 November 2017. Retrieved 25 November 2021.
  2. ↑ Almansa, Carmen; Alfón, José; de Arriba, Alberto F.; Cavalcanti, Fernando L.; Escamilla, Ignasi; Gómez, Luis A.; Miralles, Agustí; Soliva, Robert; Bartrolí, Javier (2003). "Synthesis and Structure−Activity Relationship of a New Series of COX-2 Selective Inhibitors:  1,5-Diarylimidazoles". Journal of Medicinal Chemistry. 46 (16): 3463–3475. doi:10.1021/jm030765s. ISSN 0022-2623. PMID 12877584.
Pusat Layanan

UNIVERSITAS TEKNOKRAT INDONESIA | ASEAN's Best Private University
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Phone: (0721) 702022
Email: pmb@teknokrat.ac.id