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url url url url
  2. Weltenzyklopädie
  3. کاناگلیفلوزین
کاناگلیفلوزین
از ویکی‌پدیا، دانشنامهٔ آزاد
کاناگلیفلوزین
داده‌های بالینی
تلفظ‎/ˌkænəɡlɪˈfloʊzɪn/‎ KAN-ə-glif-LOH-zin
نام‌های تجاریInvokana, Sulisent, Prominad, others
نام‌های دیگرJNJ-28431754; TA-7284; (1S)-1,5-anhydro-1-C-(3-{[5-(4-fluorophenyl)thiophen-2-yl]methyl]}-4-methylphenyl)-D-glucitol
AHFS/Drugs.commonograph
مدلاین پلاسa613033
داده‌ها
رده‌بندی داروهای
بارداری
روش مصرف داروتجویز دهانی دارو (قرص)
گروه داروییSGLT2 inhibitor
کد ATC
وضعیت قانونی
وضعیت قانونی
داده‌های فارماکوکینتیک
زیست فراهمی۶۵٪
پیوند پروتئینی۹۹٪
متابولیسمکبد گلوکورونیداسیون
نیمه‌عمر حذف11.8 (10–13) hours
دفع53% faecal and 33% kidney
شناسه‌ها
  • (2S,3R,4R,5S,6R)-2-{3-[5-[4-Fluoro-phenyl)-thiophen-2-ylmethyl]-4-methyl-phenyl}-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol
شمارهٔ سی‌ای‌اس
پاب‌کم CID
IUPHAR/BPS
دراگ‌بنک
کم‌اسپایدر
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.223.671 ویرایش در ویکی‌داده
داده‌های فیزیکی و شیمیایی
فرمول شیمیاییC۲۴H۲۵F۱O۵S۱
جرم مولی۴۴۴٫۵۲ g·mol−1
مدل سه بعدی (جی‌مول)
نقطه ذوب۹۸ درجه سلسیوس (۲۰۸ درجه فارنهایت)
  • Cc1ccc(cc1Cc2ccc(s2)c3ccc(cc3)F)[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O)O)O
  • InChI=1S/C24H25FO5S/c1-13-2-3-15(24-23(29)22(28)21(27)19(12-26)30-24)10-16(13)11-18-8-9-20(31-18)14-4-6-17(25)7-5-14/h2-10,19,21-24,26-29H,11-12H2,1H3/t19-,21-,22+,23-,24+/m1/s1 N
  • Key:XTNGUQKDFGDXSJ-ZXGKGEBGSA-N N
 N✔Y (این چیست؟)  (صحت‌سنجی)

کاناگلیفلوزین (انگلیسی: Canagliflozin) دارویی است که برای درمان دیابت نوع ۲ استفاده می شود. همراه با ورزش و رژیم غذایی استفاده می شود. مصرف آن در دیابت نوع ۱ توصیه نمی شود. از راه خوراکی مصرف می‌شود.[۲]


عوارض جانبی رایج عبارتند از عفونت‌های قارچی واژن، حالت تهوع، یبوست و عفونت‌های دستگاه ادراری. عوارض جانبی جدی ممکن است شامل قند خون پایین، گانگرن فورنیه، قطع پا، مشکلات کلیوی، پتاسیم خون بالا و فشار خون پایین باشد. کتواسیدوز دیابتی ممکن است علیرغم سطح تقریباً طبیعی قند خون رخ دهد. استفاده در بارداری و شیردهی توصیه نمی شود. کاناگلیفلوزین یک مهارکننده هم انتقال دهنده سدیم-گلوکز-۲ (SGLT2) است. این دارو با افزایش میزان گلوکز از دست رفته در ادرار عمل می‌کند.[۱]

منابع

[ویرایش]
  1. ↑ ۱٫۰ ۱٫۱ "Canagliflozin (Invokana) Use During Pregnancy". Drugs.com. Retrieved 6 April 2019.
  2. ↑ "Canagliflozin Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Retrieved 6 April 2019.

پیوند به بیرون

[ویرایش]
در ویکی‌انبار پرونده‌هایی دربارهٔ کاناگلیفلوزین موجود است.
آیکون خرد

این یک مقالهٔ خرد داروشناسی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

برگرفته از «https://fa.wikipedia.org/w/index.php?title=کاناگلیفلوزین&oldid=40807852»
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