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url url url url
  2. Weltenzyklopädie
  3. انسولین گلولیزین - ویکی‌پدیا، دانشنامهٔ آزاد
انسولین گلولیزین - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد
انسولین گلولیزین
پی‌دی‌بی 6gv0
داده‌های بالینی
نام‌های تجاریApidra, Apidra SoloStar
AHFS/Drugs.commonograph
مدلاین پلاسa607033
داده‌ها
رده‌بندی داروهای
بارداری
روش مصرف داروتزریق زیرپوستی، تزریق وریدی
کد ATC
وضعیت قانونی
وضعیت قانونی
شناسه‌ها
شمارهٔ سی‌ای‌اس
دراگ‌بنک
کم‌اسپایدر
  • none
UNII
KEGG
داده‌های فیزیکی و شیمیایی
فرمول شیمیاییC258H384N64O78S6
جرم مولی۵۸۲۲٫۶۴ g·mol−1
 N✔Y (این چیست؟)  (صحت‌سنجی)

انسولین گلولیزین (انگلیسی: Insulin glulisine) یک شکل اصلاح‌شده انسولین پزشکی با اثر سریع برای درمان دیابت نوع ۲ است که با انسولین انسانی تفاوت دارد زیرا اسید آمینه آسپاراژین در موقعیت B3 با لیزین و لیزین در موقعیت B29 با اسید گلوتامیک جایگزین می‌شود.[۴] این توسط سانوفی-آونتیس توسعه داده شد و در سال ۲۰۰۴ میلادی توسط FDA و EMA[۵] برای بازاریابی تأیید شد.[۶] با نام تجاری Apidra فروخته می‌شود.[۷] هنگامی که به صورت زیر جلدی تزریق می‌شود، زودتر از انسولین معمولی انسانی (RHI) در خون نمایان می‌شود. [۸] هنگامی که به عنوان انسولین زمان غذا استفاده می‌شود، دوز باید ۱۵ دقیقه قبل یا ۲۰ دقیقه پس از شروع غذا تجویز شود.[۹] تزریق داخل وریدی نیز ممکن است برای هیپرگلیسمی شدید مورد استفاده قرار گیرد، اما باید تحت نظارت یک متخصص پزشکی انجام شود.[۲]


شایع ترین عوارض جانبی شامل هیپوگلیسمی (سطح پایین گلوکز خون) است.

منابع

  1. ↑ ۱٫۰ ۱٫۱ "Insulin glulisine Use During Pregnancy". Drugs.com. 6 April 2020. Retrieved 21 September 2020.
  2. ↑ ۲٫۰ ۲٫۱ "Apidra- insulin glulisine injection, solution Apidra SoloStar- insulin glulisine injection, solution". DailyMed. 6 December 2019. Retrieved 21 September 2020.
  3. ↑ "Apidra EPAR". European Medicines Agency (EMA). Retrieved 7 October 2020.
  4. ↑ "Apidra (insulin glulisine) injection, solution". DailyMed.
  5. ↑ "Apidra". ema.europa.eu. Retrieved 3 December 2023.
  6. ↑ "Apidra FDA Approval History". Drugs.com. Retrieved 25 August 2022.
  7. ↑ Jasek W, ed. (2007). Austria-Codex (به آلمانی) (2007/2008 ed.). Vienna: Österreichischer Apothekerverlag. ISBN 978-3-85200-181-4.
  8. ↑ Garnock-Jones KP, Plosker GL (May 2009). "Insulin glulisine: a review of its use in the management of diabetes mellitus". Drugs. 69 (8): 1035–57. doi:10.2165/00003495-200969080-00006. PMID 19496630. S2CID 41839395.
  9. ↑ "Insulin Glulisine". Drugs.com.
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