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url url url url
  2. Weltenzyklopädie
  3. انسولین دگلودک - ویکی‌پدیا، دانشنامهٔ آزاد
انسولین دگلودک - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد
انسولین دگلودک
یک هگزامر انسولین دگلودک که در آن. زنجیره‌های A به رنگ زیتونی روشن، زنجیره‌های B به رنگ قهوه ای مایل به زرد، و اتم مرکزی روی به رنگ سبز دودی است. از پی‌دی‌بی 4AKJ.
داده‌های بالینی
AHFS/Drugs.commonograph
داده‌ها
رده‌بندی داروهای
بارداری
روش مصرف داروتزریق زیرجلدی
کد ATC
وضعیت قانونی
وضعیت قانونی
شناسه‌ها
  • B29N(ε)-ω-carboxypentadecanoyl-γ-L-glutamyl desB30 human insulin
شمارهٔ سی‌ای‌اس
پاب‌کم SID
کم‌اسپایدر
  • none
UNII
KEGG
داده‌های فیزیکی و شیمیایی
فرمول شیمیاییC274H411N65O81S6
جرم مولی۶۱۰۴٫۰۴ g·mol−1
  (صحت‌سنجی)

انسولین دگلودک(به انگلیسی: Insulin degludec) (INN /USAN) یک آنالوگ انسولین بسیار طولانی اثر است که توسط نوو نوردیسک با نام تجاری Tresiba ساخته شده‌است.[۱] این دارو به شکل تزریق زیر جلدی و یک بار در روز تجویز می‌شود تا به بیمار مبتلا به دیابت در کنترل سطح قند خون کمک کند. مدت زمان اثرگذاری این نوع انسولین تا ۴۲ ساعت طول می‌کشد (در مقایسه با سایر انسولین‌های طولانی اثر همچون انسولین گلارژین و انسولین دتمیر که ۱۸ تا ۲۶ اثر دارند). این موضوع موجب می‌شود تا بتوان از آن به صورت یک بار در روز استفاده کرد.[۲][۳][۴]

در سال ۲۰۱۷، این دارو با بیش از یک میلیون نسخه ، ۲۶۵مین داروی رایج در ایالات متحده بود.[۵][۶]

منابع

  1. ↑ CHMP (October 18, 2012), "Summary of opinion 1 (initial authorisation): Tresiba" (PDF), Pending EC decisions (PDF), آژانس دارویی اروپا, archived from the original (PDF) on 11 January 2017, retrieved November 6, 2012
  2. ↑ Klein O, Lynge J, Endahl L, Damholt B, Nosek L, Heise T (May 2007). "Albumin-bound basal insulin analogues (insulin detemir and NN344): comparable time-action profiles but less variability than insulin glargine in type 2 diabetes". Diabetes, Obesity & Metabolism. 9 (3): 290–9. doi:10.1111/j.1463-1326.2006.00685.x. PMID 17391154. S2CID 23810204.
  3. ↑ Haahr H, Heise T (September 2014). "A review of the pharmacological properties of insulin degludec and their clinical relevance". Clinical Pharmacokinetics. 53 (9): 787–800. doi:10.1007/s40262-014-0165-y. PMC 4156782. PMID 25179915.
  4. ↑ "Tresiba Summary of product characteristics" (PDF). European Medicines Agency.
  5. ↑ "The Top 300 of 2020". ClinCalc. Retrieved 11 April 2020.
  6. ↑ "Insulin Degludec - Drug Usage Statistics". ClinCalc. Retrieved 11 April 2020.

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