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url url url url
  2. Weltenzyklopädie
  3. رموگلیفلوزین اتابونات - ویکی‌پدیا، دانشنامهٔ آزاد
رموگلیفلوزین اتابونات - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد
رموگلیفلوزین اتابونات
داده‌های بالینی
روش مصرف داروخوراکی
کد ATC
  • None
وضعیت قانونی
وضعیت قانونی
  • Investigational
داده‌های فارماکوکینتیک
متابولیسمRemoglifozin is metabolized primarily by cytochrome P450 (CYP) 3A4 and to a lesser extent by CYP2C19 to GSK 279782 (the active metabolite) and GSK 333081 before being glucuronidated to generate inactive glucuronide conjugates.[۱]
شناسه‌ها
  • 5-Methyl-4-[4-(1-methylethoxy)benzyl]-1-(1-methylethyl)-1H-pyrazol-3-yl 6-O-(ethoxycarbonyl)-β-D-glucopyranoside
شمارهٔ سی‌ای‌اس
کم‌اسپایدر
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
داده‌های فیزیکی و شیمیایی
فرمول شیمیاییC26H38N2O9
جرم مولی۵۲۲٫۵۹۵ g·mol−1
مدل سه بعدی (جی‌مول)
  • OC1C(COC(=O)OCC)OC(C(O)C1O)Oc(nn(C(C)C)c2C)c2Cc3ccc(cc3)OC(C)C
  • InChI=1S/C26H38N2O9/c1-7-33-26(32)34-13-20-21(29)22(30)23(31)25(36-20)37-24-19(16(6)28(27-24)14(2)3)12-17-8-10-18(11-9-17)35-15(4)5/h8-11,14-15,20-23,25,29-31H,7,12-13H2,1-6H3/t20-,21-,22+,23-,25+/m1/s1 N
  • Key:UAOCLDQAQNNEAX-ABMICEGHSA-N N
 N✔Y (این چیست؟)  (صحت‌سنجی)

رموگلیفلوزین اتابونات (انگلیسی: Remogliflozin etabonate) دارویی از دسته گلیفلوزین برای درمان استئاتوهپاتیت غیر الکلی (NASH) و دیابت نوع ۲ است.[۲]

مکانیسم عمل

رموگلیفلوزین اتابونات یک پیش‌داروی رموگلیفلوزین است. رموگلیفلوزین پروتئین‌های انتقال سدیم-گلوکز (SGLT) را که مسئول بازجذب گلوکز در کلیه هستند، مهار می‌کند. مسدود کردن این ناقل باعث می شود که گلوکز خون از طریق ادرار دفع شود. رموگلیفلوزین برای SGLT2 انتخابی است.[۳]

منابع

  1. ↑ Markham, A.J.D., Remogliflozin etabonate: first global approval. 2019. 79(10): p. 1157-1161.
  2. ↑ Statement on a nonproprietory name adopted by the USAN council
  3. ↑ "Molecule of the Month: Dapagliflozin". Prous Science. November 2007. Archived from the original on January 6, 2008.
آیکون خرد

این یک مقالهٔ خرد داروشناسی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

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