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url url
  2. Weltenzyklopädie
  3. فنیپرازین - ویکی‌پدیا، دانشنامهٔ آزاد
فنیپرازین - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد
فنیپرازین
داده‌های بالینی
روش مصرف داروخوراکی
کد ATC
  • None
وضعیت قانونی
وضعیت قانونی
  • دیگر عرضه نمی‌شود
شناسه‌ها
  • (1-Methyl-2-phenyl-ethyl)hydrazine
شمارهٔ سی‌ای‌اس
پاب‌کم CID
کم‌اسپایدر
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.000.215 ویرایش در ویکی‌داده
داده‌های فیزیکی و شیمیایی
فرمول شیمیاییC9H14N2
جرم مولی۱۵۰٫۲۲۵ g·mol−1
  • InChI=1S/C9H14N2/c1-8(11-10)7-9-5-3-2-4-6-9/h2-6,8,11H,7,10H2,1H3 ✔Y
  • Key:VXTWEDPZMSVFEF-UHFFFAOYSA-N ✔Y
  (صحت‌سنجی)

فنیپرازین (INN؛ با نام‌های آمفتیدرازین و آمفتامین هیدرازید و نام‌های تجاری Catron و Cavodil شناخته می‌شود) یک بازدارنده مونوآمین اکسیداز غیرقابل بازگشت و غیر انتخابی (MAOI) و از کلاس شیمیایی هیدرازین‌ها است که به عنوان ضد افسردگی در دهه ۱۹۶۰ استفاده می‌شد.[۱][۲][۳] این دارو همچنین در درمان آنژین صدری و اسکیزوفرنی مورد استفاده قرار گرفت.[۴][۵] به دلیل نگرانی از سمیت این ماده که منجر به علائمی همچون یرقان، تنبلی چشم و التهاب عصب بینایی می‌شد، استفاده از آن تا حد زیادی کاهش پیدا کرده و متوقف شد.[۶][۷][۸]

منابع

  1. ↑ Lear TE, Browne MW, Greeves JA (November 1962). "A controlled trial of cavodil (pheniprazine) in depression". The Journal of Mental Science. 108 (457): 856–58. doi:10.1192/bjp.108.457.856. PMID 13928843.
  2. ↑ Fagervall I, Ross SB (April 1986). "Inhibition of monoamine oxidase in monoaminergic neurones in the rat brain by irreversible inhibitors". Biochemical Pharmacology. 35 (8): 1381–7. doi:10.1016/0006-2952(86)90285-6. PMID 2870717.
  3. ↑ Eberson LE, Persson K (July 1962). "Studies on Monoamine Oxidase Inhibitors. I. The Autoxidation of β-Phenylisopropylhydrazine as a Model Reaction for Irreversible Monoamine Oxidase Inhibition". Journal of Medicinal and Pharmaceutical Chemistry. 91 (4): 738–52. doi:10.1021/jm01239a006. PMID 14056405.
  4. ↑ Sandler G (March 1961). "Clinical evaluation of pheniprazine in angina pectoris". British Medical Journal. 1 (5228): 792–4. doi:10.1136/bmj.1.5228.792. PMC 1953879. PMID 13746179.
  5. ↑ Wickstrom L, Hahn N (September 1962). "[beta-Phenylisoprophlhydrazine (Catran) in schizophrenia]". Nordisk Medicin. 68: 1165–7. PMID 14000469.
  6. ↑ Fentem PH, Howitt G (December 1961). "Fatal jaundice after administration of pheniprazine". British Medical Journal. 2 (5267): 1616–7. doi:10.1136/bmj.2.5267.1616. PMC 1970739. PMID 13892290.
  7. ↑ Frandsen E (1962). "Toxic amblyopia during antidepressant treatment with pheniprazine (Catran)". Acta Psychiatrica Scandinavica. 38 (1): 1–14. doi:10.1111/j.1600-0447.1962.tb01780.x. PMID 13894598. S2CID 35152293.
  8. ↑ Thomsen NJ (January 1963). "[Optic neuritis after treatment with Catran]". Ugeskrift for Laeger. 125: 138–9. PMID 13981222.
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