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url url
  2. Weltenzyklopädie
  3. کلوتیازپام - ویکی‌پدیا، دانشنامهٔ آزاد
کلوتیازپام - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد
کلوتیازپام
داده‌های بالینی
نام‌های تجاریVeratran, Rize, Clozan
AHFS/Drugs.comInternational Drug Names
روش مصرف داروخوراکی، زیر زبانی، قطره
کد ATC
وضعیت قانونی
وضعیت قانونی
داده‌های فارماکوکینتیک
زیست فراهمی~۹۰٪
متابولیسمکبد
نیمه‌عمر حذف۴ ساعت[۱]
دفعکلیه
شناسه‌ها
  • 5-(2-chlorophenyl)-7-ethyl-1-methyl-3H-thieno[2,3-e][1,4]diazepin-2-one
شمارهٔ سی‌ای‌اس
پاب‌کم CID
دراگ‌بنک
کم‌اسپایدر
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.046.920 ویرایش در ویکی‌داده
داده‌های فیزیکی و شیمیایی
فرمول شیمیاییC16H15ClN2OS
جرم مولی۳۱۸٫۸۲ g·mol−1
مدل سه بعدی (جی‌مول)
  • ClC1=C(C2=NCC(N(C)C3=C2C=C(CC)S3)=O)C=CC=C1
  • InChI=1S/C16H15ClN2OS/c1-3-10-8-12-15(11-6-4-5-7-13(11)17)18-9-14(20)19(2)16(12)21-10/h4-8H,3,9H2,1-2H3 ✔Y
  • Key:CHBRHODLKOZEPZ-UHFFFAOYSA-N ✔Y
 N✔Y (این چیست؟)  (صحت‌سنجی)

کلوتیازپام (به انگلیسی: Clotiazepam)[۲] (با نام تجاری Clozan ,Distensan ,Trecalmo ,Rize ,Rizen و Veratran به بازار عرضه می‌شود) یک داروی تینودیازپینی است که آنالوگ بنزودیازپین محسوب می‌شود. تفاوت مولکول کلوتیازپام با بنزودیازپین‌ها از این جهت است که در آن حلقه بنزن توسط یک حلقه تیوفن جایگزین شده‌است.[۳] این ماده دارای خاصیت ضد اضطراب،[۴] شل کننده عضلات اسکلتی،[۵]ضد تشنج و آرام بخش است.[۶] مرحله ۲ خواب NREM به‌طور قابل توجهی توسط کلوتیازپام افزایش می‌یابد.[۷]

جستارهای وابسته

منابع

  1. ↑ https://www.has-sante.fr/upload/docs/evamed/CT-14195_VERATRAN_PIC_REEVAL_RI_Avis2_CT14195.pdf
  2. ↑ DE Patent 2107356
  3. ↑ Niwa T, Shiraga T, Ishii I, Kagayama A, Takagi A (September 2005). "Contribution of human hepatic cytochrome p450 isoforms to the metabolism of psychotropic drugs" (PDF). Biol. Pharm. Bull. 28 (9): 1711–6. doi:10.1248/bpb.28.1711. PMID 16141545.[پیوند مرده]
  4. ↑ Klicpera, C.; Strian, F. (May 1978). "Autonomic perception and responses in anxiety-inducing situations". Pharmakopsychiatr Neuropsychopharmakol. 11 (3): 113–20. doi:10.1055/s-0028-1094569. PMID 27828.
  5. ↑ Fukuda, T.; Tsumagari, T. (Aug 1983). "Effects of psychotropic drugs on the rage responses induced by electrical stimulation of the medial hypothalamus in cats" (PDF). Jpn J Pharmacol. 33 (4): 885–90. doi:10.1254/jjp.33.885. PMID 6632385.[پیوند مرده]
  6. ↑ Mandrioli, R.; Mercolini, L.; Raggi, MA. (Oct 2008). "Benzodiazepine metabolism: an analytical perspective". Curr Drug Metab. 9 (8): 827–44. doi:10.2174/138920008786049258. PMID 18855614.
  7. ↑ Nakazawa Y; Kotorii M; Oshima M; Horikawa S; Tachibana H. (October 31, 1975). "Effects of thienodiazepine derivatives on human sleep as compared to those of benzodiazepine derivatives". Psychopharmacologia. 44 (2): 165–71. doi:10.1007/BF00421005. PMID 709.

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