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url url url url
  2. Weltenzyklopädie
  3. کاروکسازون - ویکی‌پدیا، دانشنامهٔ آزاد
کاروکسازون - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد
کاروکسازون
داده‌های بالینی
رده‌بندی داروهای
بارداری
  • ?
روش مصرف داروخوراکی
کد ATC
  • None
وضعیت قانونی
وضعیت قانونی
  • ℞ (Prescription only)
شناسه‌ها
  • 2-(2-oxo-4H-1,3-benzoxazin-3-yl)acetamide
شمارهٔ سی‌ای‌اس
پاب‌کم CID
کم‌اسپایدر
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.038.481 ویرایش در ویکی‌داده
داده‌های فیزیکی و شیمیایی
فرمول شیمیاییC10H10N2O3
جرم مولی۲۰۶٫۲۰۱ g·mol−1
مدل سه بعدی (جی‌مول)
  • O=C(N)CN2C(=O)Oc1ccccc1C2

کاروکسازون (Surodil و Timostenil) یک داروی ضد افسردگیست که قبلاً برای درمان اختلال افسردگی عمده استفاده می‌شد اما اکنون دیگر به بازار عرضه نمی‌شود.[۱][۲] این ماده به عنوان یک بازدارنده برگشت‌پذیر مونوآمین اکسیداز (RIMA) بر هر دو زیرگروه MAO-A و MAO-B عمل می‌کند.[۳][۴][۵][۶][۷]

سنتز

سنتز کاروکسازون:[۸][۹][۱۰][۱۱]

سنتز با آمین‌دار کردن کاهشی سالیسیل‌آلدهید و گلیسینامید شروع شده و گونه 3 ایجاد می‌شود. سپس از واکنش این گونه با فسژن و سدیم هیدروژن‌کربنات، فرایند تکمیل می‌شود.

جستارهای وابسته

منابع

  1. ↑ Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN 0-412-54090-8.
  2. ↑ Cecchini S, Petri P, Ardito R, Bareggi SR, Torriti A (1978). "A comparative double-blind trial of the new antidepressant caroxazone and amitriptyline". The Journal of International Medical Research. 6 (5): 388–94. doi:10.1177/030006057800600507. PMID 359383. S2CID 40464443.
  3. ↑ Monoamine oxidase inhibitors in neurological diseases. New York: M. Dekker. 1994. ISBN 0-8247-9082-0.
  4. ↑ Moretti A, Caccia C, Martini A, Bonollo L, Amico A, Sega R, et al. (May 1981). "Effect of caroxazone, a new antidepressant drug, on monoamine oxidases in healthy volunteers". British Journal of Clinical Pharmacology. 11 (5): 511–5. doi:10.1111/j.1365-2125.1981.tb01158.x. PMC 1401585. PMID 7272163.
  5. ↑ Moretti A, Caccia C, Calderini G, Menozzi M, Amico A (October 1981). "Studies on the mechanism of action of caroxazone, a new antidepressant drug". Biochemical Pharmacology. 30 (19): 2728–31. doi:10.1016/0006-2952(81)90549-9. PMID 6170295.
  6. ↑ Martini A, Bonollo L, Nicolis FB, Sega R, Palermo A (June 1981). "Effects of caroxazone, a reversible monoamine oxidase inhibitor, on the pressor response to oral tyramine in man". British Journal of Clinical Pharmacology. 11 (6): 611–5. doi:10.1111/j.1365-2125.1981.tb01178.x. PMC 1402186. PMID 7272178.
  7. ↑ Martini A, Bonollo L, Nicolis FB, Sega R, Palermo A, Braibanti E (June 1981). "Effects of caroxazone, a reversible monoamine oxidase inhibitor, on the pressor response to intravenous tyramine in man". British Journal of Clinical Pharmacology. 11 (6): 605–10. doi:10.1111/j.1365-2125.1981.tb01177.x. PMC 1402193. PMID 7272177.
  8. ↑ Bernardi L, Coda S, Nicolella V, Vicario GP, Gioia B, Minghetti A, et al. (1979). "Radioisotopic and synthetic studies related to caroxazone metabolism in man". Arzneimittel-Forschung. 29 (9): 1412–6. PMID 583252.
  9. ↑ Bernardi L, Coda S, Pegrassi L, Suchowsky GK (August 1968). "Pharmacological properties of some derivatives of 1,3-benzoxazine". Experientia. 24 (8): 774–5. doi:10.1007/bf02144859. PMID 5683159. S2CID 30917127.
  10. ↑ Bernardi L, Coda S, Bonsignori A, Pegrassi L, Suchowsky GK (August 1969). "Central depressant properties of 3,1-benzoxazine derivates". Experientia. 25 (8): 787–8. doi:10.1007/bf01897874. PMID 5348526. S2CID 5347811.
  11. ↑ GB 1115759 ; L. Bernardi et al. , U.S. Patent ۳٬۴۲۷٬۳۱۳ (1965, 1969 both to Soc. Farma. Italia).
Pusat Layanan

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