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url url url url
  2. Weltenzyklopädie
  3. ایپرونیازید - ویکی‌پدیا، دانشنامهٔ آزاد
ایپرونیازید - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد
ایپرونیازید
داده‌های بالینی
AHFS/Drugs.comInternational Drug Names
کد ATC
داده‌های فارماکوکینتیک
زیست فراهمی1
شناسه‌ها
  • N-isopropylisonicotinohydrazide
شمارهٔ سی‌ای‌اس
پاب‌کم CID
دراگ‌بنک
کم‌اسپایدر
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.000.199 ویرایش در ویکی‌داده
داده‌های فیزیکی و شیمیایی
فرمول شیمیاییC9H13N3O
جرم مولی۱۷۹٫۲۲۳ g·mol−1
مدل سه بعدی (جی‌مول)
چگالی1.084 g/cm3
نقطه جوش۲۶۵٫۹ درجه سلسیوس (۵۱۰٫۶ درجه فارنهایت)
  • O=C(NNC(C)C)c1ccncc1
  • InChI=1S/C9H13N3O/c1-7(2)11-12-9(13)8-3-5-10-6-4-8/h3-7,11H,1-2H3,(H,12,13) ✔Y
  • Key:NYMGNSNKLVNMIA-UHFFFAOYSA-N ✔Y
  (صحت‌سنجی)

ایپرونیازید (Marsilid, Rivivol, Euphozid, Iprazid , Ipronid, Ipronin) یک مهار کننده مونوآمین اکسیداز(MAOI) غیر انتخابی و برگشت‌ناپذیر از دسته هیدرازین‌ها است.[۱][۲]

این ماده یک بیگانه‌زیست است که در ابتدا برای درمان سل طراحی شده بود، اما بعداً به عنوان داروی ضد افسردگی مورد استفاده قرار گرفت. با این حال، به دلیل سمیت کبدی از بازار حذف شد.[۳][۴] استفاده پزشکی از ایپرونیازید در دهه ۱۹۶۰ در بیشتر جهان متوقف شد، اما در فرانسه همچنان مورد استفاده قرار گرفت.

جستارهای وابسته

منابع

  1. ↑ Robert A. Maxwell; Shohreh B. Eckhardt (1990). Drug discovery. Humana Press. pp. 143–154. ISBN 9780896031807.
  2. ↑ Fagervall I, Ross SB (April 1986). "Inhibition of monoamine oxidase in monoaminergic neurones in the rat brain by irreversible inhibitors". Biochemical pharmacology. 35 (8): 1381–7. doi:10.1016/0006-2952(86)90285-6. PMID 2870717.
  3. ↑ Timbrell, John (2008). Taylor & Francis Group (به انگلیسی). pp. 324–326. doi:10.3109/9781420007084. ISBN 978-0-8493-7302-2.
  4. ↑ Henn, Fritz; Sartorius, Norman; Helmchen, Hanfried; Lauter, Hans (2013-11-11). Contemporary Psychiatry (به انگلیسی). Springer Science & Business Media. p. 109. ISBN 9783642595196.
Pusat Layanan

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