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url url url url
  2. Weltenzyklopädie
  3. زونیساماید - ویکی‌پدیا، دانشنامهٔ آزاد
زونیساماید - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد
زونیساماید
Ball-and-stick model of the zonisamide molecule
داده‌های بالینی
نام‌های تجاریZonegran
AHFS/Drugs.commonograph
مدلاین پلاسa603008
داده‌ها
رده‌بندی داروهای
بارداری
  • AU: D
روش مصرف داروخوراکی
کد ATC
وضعیت قانونی
وضعیت قانونی
داده‌های فارماکوکینتیک
زیست فراهمی~۱۰۰٪[۱]
پیوند پروتئینی۴۰٪[۱]
متابولیسمکبدی از طریق آنزیم CYP3A4[۱]
نیمه‌عمر حذف۶۳ ساعت در پلاسمای خون[۱]
دفعکلیوی (۶۲٪)؛ مدفوع (۳٪)[۱]
شناسه‌ها
  • benzo[d]isoxazol-3-ylmethanesulfonamide
شمارهٔ سی‌ای‌اس
پاب‌کم CID
IUPHAR/BPS
دراگ‌بنک
کم‌اسپایدر
UNII
KEGG
ChEBI
ChEMBL
لیگاند بانک داده پروتئین
CompTox Dashboard (EPA)
ECHA InfoCard100.118.526 ویرایش در ویکی‌داده
داده‌های فیزیکی و شیمیایی
فرمول شیمیاییC8H8N2O3S۱
جرم مولی212.227 g/mol g·mol−1
مدل سه بعدی (جی‌مول)
نقطه ذوب۱۶۲ درجه سلسیوس (۳۲۴ درجه فارنهایت)
  • O=S(=O)(N)Cc2noc1ccccc12
  • InChI=1S/C8H8N2O3S/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7/h1-4H,5H2,(H2,۹٬۱۱٬۱۲) ✔Y
  • Key:UBQNRHZMVUUOMG-UHFFFAOYSA-N ✔Y
  (صحت‌سنجی)

زونیساماید (انگلیسی: Zonisamide) دارویی است که در درمان صرع و بیماری پارکینسون استفاده می‌شود.[۲][۳]

از لحاظ شیمیایی، این دارو یک سولفونامید است و به عنوان درمان کمکی در بیماری پارکینسون، تشنج پارشیال، سندرم لنوکس-گستو، صرع میوکلونیک و صرع تونیک-کلونیک منتشر کاربرد دارد.[۴] علاوه بر این، زونیساماید گاهی به‌صورت تک‌دارو برای درمان صرع پارشیال تجویز می‌شود.[۳][۵]

پژوهش‌هایی جهت استفاده از آن در درمان چاقی،[۶][۷][۸][۹] میگرن[۳] و اختلال دوقطبی[۱۰][۱۱] انجام شده‌است.

شایع‌ترین عوارض این دارو شامل بی‌اشتهایی، خواب‌آلودگی، گیجی، تحریک‌پذیری عصبی، افسردگی، دوبینی، اختلالات حافظه و کاهش سطح بی‌کربنات خون است.[۱][۱۲][۱۳]

تداخلات دارویی

زونیساماید با داروهای ذیل تداخل دارویی دارد:

منابع

  1. ↑ ۱٫۰ ۱٫۱ ۱٫۲ ۱٫۳ ۱٫۴ ۱٫۵ "Zonegran® Product Information" (PDF). TGA eBusiness Services. SciGen (Australia) Pty Ltd. 4 April 2013. Retrieved 18 November 2013.
  2. ↑ Grover, ND; Limaye, RP; Gokhale, DV; Patil, TR (November–December 2013). "Zonisamide: a review of the clinical and experimental evidence for its use in Parkinson's disease". Indian Journal of Pharmacology. 45 (6): 547–55. doi:10.4103/0253-7613.121266. PMC 3847242. PMID 24347760.
  3. ↑ ۳٫۰ ۳٫۱ ۳٫۲ Brayfield, A, ed. (8 March 2016). "Zonisamide: Martindale: The Complete Drug Reference". MedicinesComplete. London, UK: Pharmaceutical Press. Retrieved 19 August 2017.
  4. ↑ Souney, P; Mutnick, A; Shargel, L (2007). Comprehensive Pharmacy Review (6th ed.). Williams & Wilkins. p. 988. ISBN 9780781765619. OCLC 869677890.{{cite book}}: نگهداری یادکرد:نام‌های متعدد:فهرست نویسندگان (link)
  5. ↑ Rossi, S, ed. (2013). Australian Medicines Handbook (2013 ed.). Adelaide: The Australian Medicines Handbook Unit Trust. ISBN 978-0-9805790-9-3.
  6. ↑ Gadde, KM; Franciscy, DM; Wagner, II, HR; Krishnan, KRR (April 2003). "Zonisamide for Weight Loss in Obese Adults: A Randomized Controlled Trial". Journal of the American Medical Association. 289 (14): 1820–1825. doi:10.1001/jama.289.14.1820. PMID 12684361.
  7. ↑ University of Cincinnati (2005). "Zonegran in the Treatment of Binge Eating Disorder Associated With Obesity". ClinicalTrials.gov. Retrieved 2006-05-04.
  8. ↑ Tuscaloosa Research; Education Advancement Corporation (2005). "Zonegran for the Treatment of Weight Gain Associated With Psychotropic Medication Use: A Placebo-Controlled Trial". ClinicalTrials.gov. Retrieved 2006-05-04.
  9. ↑ National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) (2006). "Zonisamide for Weight Reduction in Obese Adults". ClinicalTrials.gov. Retrieved 2006-05-04.
  10. ↑ Brian D. Loftus (2004). "Zonegran". Retrieved 2006-11-29.
  11. ↑ Hasegawa, H (May 2004). "utilization of zonisamide in patients with chronic pain or epilepsy refractory to other treatments: a retrospective, open label, uncontrolled study in a VA hospital". Curr Med Res Opin. 20 (5): 577–580. doi:10.1185/030079904125003313. PMID 15140322.
  12. ↑ "Zonegran 25, 50, 100 mg Hard Capsules". electronic Medicines Compendium. Eisai Ltd. 8 October 2013. Retrieved 18 November 2013.
  13. ↑ "zonisamide (Rx) - Zonegran". Medscape Reference. WebMD. Retrieved 18 November 2013.
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