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url url url url
  2. Weltenzyklopädie
  3. ریلوزول - ویکی‌پدیا، دانشنامهٔ آزاد
ریلوزول - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد
ریلوزول
داده‌های بالینی
نام‌های تجاریRilutek
AHFS/Drugs.commonograph
مدلاین پلاسa696013
کد ATC
شناسه‌ها
  • 6-(trifluoromethoxy)benzothiazol-2-amine
شمارهٔ سی‌ای‌اس
پاب‌کم CID
IUPHAR/BPS
دراگ‌بنک
کم‌اسپایدر
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.124.754 ویرایش در ویکی‌داده
داده‌های فیزیکی و شیمیایی
فرمول شیمیاییC8H5F3N2OS
جرم مولی234.199 g/mol g·mol−1
مدل سه بعدی (جی‌مول)
  • FC(F)(F)Oc1ccc2nc(sc2c1)N
  • InChI=1S/C8H5F3N2OS/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5/h1-3H,(H2,12,13) ✔Y
  • Key:FTALBRSUTCGOEG-UHFFFAOYSA-N ✔Y
  (صحت‌سنجی)

ریلوزول (به انگلیسی: Riluzole)

رده درمانی: بلوک‌کننده گلوتامات

اشکال دارویی: قرص

موارد مصرف

ریلوزول در درمان اسکلروز جانبی آمیوتروفیک ALS مصرف می‌شود. به نظر می‌رسد در درمان اختلالات خلقی و افسردگی نیز ممکن است سودمند باشد.

مکانیسم اثر

یک ویژگی شایع ملانوما و ALS افزایش میزان اسید امینه گلوتامات است. این اسید آمینه یک فاکتور رشد سلولی است که می‌تواند نورون‌ها را بیش از حد تحریک کند تا جایی که خاموش شوند. احتمالاً در ALS و ملانوما تولید بیش از حد گلوتامات سبب رشد و گسترش بیماری می‌شود.ریلوزول با بلوک نوعی از کانال‌های سدیم به صورت غیر مستقیم و با بلوک گیرنده‌های گلوتامات به صورت مستقیم اثر گلوتامات بر نورونهای حرکتی را مهار می‌کند.

عوارض جانبی

تهوع، خستگی و مشکلات کبدی

جستارهای وابسته

منابع

  • حشمتی، پونه (۱۳۸۷). فرهنگ داروهای ژنریک ایران.
Pusat Layanan

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