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faculty of Economics and Business
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Faculty of Letters and Educational Sciences
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teknopedia

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url url
  2. Weltenzyklopädie
  3. (آر)-۳-نیتروبی‌فنیلین - ویکی‌پدیا، دانشنامهٔ آزاد
(آر)-۳-نیتروبی‌فنیلین - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد
(R)-3-Nitrobiphenyline
داده‌های بالینی
مدلاین پلاسa682611
شناسه‌ها
  • (R)-2-[1-(3'-Nitrobiphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole
شمارهٔ سی‌ای‌اس
پاب‌کم CID
کم‌اسپایدر
ChEMBL
CompTox Dashboard (EPA)
داده‌های فیزیکی و شیمیایی
فرمول شیمیاییC17H17N3O3
جرم مولی۳۱۱٫۳۴۱ g·mol−1
مدل سه بعدی (جی‌مول)
  • c2ccc([N](=O)=O)cc2-c1ccccc1OC(C)C3=NCCN3
  • InChI=1S/C17H17N3O3/c1-12(17-18-9-10-19-17)23-16-8-3-2-7-15(16)13-5-4-6-14(11-13)20(21)22/h2-8,11-12H,9-10H2,1H3,(H,18,19)/t12-/m1/s1 ✔Y
  • Key:NMSAVNXFCXMJJY-GFCCVEGCSA-N ✔Y
  (صحت‌سنجی)

(آر)-۳-نیتروبی‌فنیلین (انگلیسی: (R)-3-Nitrobiphenyline) دارویی است که به عنوان آگونیست α2-آدرنرژیک، انتخابی برای زیرگروه α2C، و همچنین یک آنتاگونیست ضعیف در زیرگروه های α2A و α2B عمل می کند. در پژوهش های علمی برای مشخص کردن خواص اتصال و عملکرد زیرگروه α2C استفاده شده است.[۱][۲]

منابع

  1. ↑ Crassous PA, Cardinaletti C, Carrieri A, Bruni B, Di Vaira M, Gentili F, Ghelfi F, Giannella M, Paris H, Piergentili A, Quaglia W, Schaak S, Vesprini C, Pigini M (August 2007). "Alpha2-adrenoreceptors profile modulation. 3.1 (R)-(+)-m-nitrobiphenyline, a new efficient and alpha2C-subtype selective agonist". Journal of Medicinal Chemistry. 50 (16): 3964–8. doi:10.1021/jm061487a. PMID 17630725.
  2. ↑ Del Bello, Fabio; Mattioli, Laura; Ghelfi, Francesca; Giannella, Mario; Piergentili, Alessandro; Quaglia, Wilma; Cardinaletti, Claudia; Perfumi, Marina; Thomas, Russell J.; Zanelli, Ugo; Marchioro, Carla; Dal Cin, Michele; Pigini, Maria (11 November 2010). "Fruitful Adrenergic α2C-Agonism/α2A-Antagonism Combination to Prevent and Contrast Morphine Tolerance and Dependence". Journal of Medicinal Chemistry. 53 (21): 7825–7835. doi:10.1021/jm100977d. PMID 20925410.
آیکون خرد

این یک مقالهٔ خرد داروشناسی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

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