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url url
  2. Weltenzyklopädie
  3. فن‌متوزول - ویکی‌پدیا، دانشنامهٔ آزاد
فن‌متوزول - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد
فن‌متوزول
داده‌های بالینی
کد ATC
  • None
شناسه‌ها
  • 2-[(3,4-dichlorophenoxy)methyl]-4,5-dihydro-1H-imidazole
شمارهٔ سی‌ای‌اس
پاب‌کم CID
کم‌اسپایدر
UNII
ChEMBL
CompTox Dashboard (EPA)
داده‌های فیزیکی و شیمیایی
فرمول شیمیاییC10H10Cl2N2O
جرم مولی۲۴۵٫۱۰ g·mol−1
مدل سه بعدی (جی‌مول)
  • Clc2ccc(OCC/1=N/CCN\1)cc2Cl

فن‌متوزول (انگلیسی: Fenmetozole) دارویی است که به عنوان یک داروی ضد افسردگی ثبت شده است[۱][۲]، اما بعداً به عنوان یک آنتاگونیست اثرات اتانول مورد مطالعه قرار گرفت، اگرچه نتایج ضعیف بود و حتی در برخی موارد اثرات آن را افزایش داد.[۳][۴][۵][۶][۷] این دارو به عنوان یک آنتاگونیست گیرنده α2-آدرنرژیک مشابه سایر ایمیدازول ها مانند ایدازوکسان عمل می کند.[۸] این دارو هرگز به بازار عرضه نشد.

فنوکسازولین همان فرمول دقیق را دارد، البته به جای 3',4'-dich، یک گروه ارتو ایزوپروپیل به جای آن انتخاب شد.

منابع

  1. ↑ Dictionary of organic compounds. London: Chapman & Hall. 1996. ISBN 0-412-54090-8.
  2. ↑ David J. Triggle (1997). Dictionary of pharmacological agents. London: Chapman & Hall. ISBN 0-412-46630-9.
  3. ↑ McNamee HB, Mendelson JH, Korn J (June 1975). "Fenmetozole in acute alcohol intoxication in man". Clinical Pharmacology and Therapeutics. 17 (6): 735–7. doi:10.1002/cpt1975176735. PMID 1095283. S2CID 68796969.
  4. ↑ Griffis LC, Bright TP, Cerimele BJ, Forney RB (September 1978). "Combined effects of fenmetozole and ethanol". Clinical Pharmacology and Therapeutics. 24 (3): 350–3. doi:10.1002/cpt1978243350. PMID 357069. S2CID 9289874.
  5. ↑ Frye GD, Breese GR, Mailman RB, Vogel RA, Ondrusek MG, Mueller RA (1980). "An evaluation of the selectivity of fenmetozole (DH-524) reversal of ethanol-induced changes in central nervous system function". Psychopharmacology. 69 (2): 149–55. doi:10.1007/BF00427641. PMID 6256788. S2CID 25303633.
  6. ↑ Vogel RA, Frye GD, Koepke KM, Mailman RB, Mueller RA, Breese GR (1981). "Differential effects of TRH, amphetamine, naloxone, and fenmetozole on ethanol actions: attenuation of the effects of punishment and impairment of aerial righting reflex". Alcoholism: Clinical and Experimental Research. 5 (3): 386–92. doi:10.1111/j.1530-0277.1981.tb04921.x. PMID 6792942.
  7. ↑ Frye GD, Breese GR (1981). "An evaluation of the locomotor stimulating action of ethanol in rats and mice". Psychopharmacology. 75 (4): 372–9. doi:10.1007/BF00435856. PMID 6803283. S2CID 34953445.
  8. ↑ Stillings MR, England CD, Welbourn AP, Smith CF (September 1986). "Effect of methoxy substitution on the adrenergic activity of three structurally related alpha 2-adrenoreceptor antagonists". Journal of Medicinal Chemistry. 29 (9): 1780–3. doi:10.1021/jm00159a037. PMID 2875186.
آیکون خرد

این یک مقالهٔ خرد داروشناسی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

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