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url url url url
  2. Weltenzyklopädie
  3. C-Raf - ویکی‌پدیا، دانشنامهٔ آزاد
C-Raf - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد
RAF1
ساختارهای موجود
PDBجستجوی هم‌ساخت‌شناسی: PDBe RCSB
معین‌کننده‌ها
نام‌های دیگرRAF1, Raf-1 proto-oncogene, serine/threonine kinase, CMD1NN, CRAF, NS5, Raf-1, c-Raf
شناسه‌های بیرونیOMIM: 164760 MGI: 97847 HomoloGene: 48145 GeneCards: RAF1
هم‌ساخت‌شناسی
گونه‌هاانسانموش
Entrez

5894

110157

آنسامبل

ENSG00000132155

ENSMUSG00000000441

یونی‌پروت

P04049

Q99N57

RefSeq (mRNA)

NM_002880، XM_005265355، XM_005265357، XM_005265358، XM_005265359، XM_011533974، XM_017006966، XR_001740226، XR_001740227 XM_011533975، NM_002880، XM_005265355، XM_005265357، XM_005265358، XM_005265359، XM_011533974، XM_017006966، XR_001740226، XR_001740227

XM_006505364، NM_001356333، NM_001356334، XM_030255098، XM_030255099 NM_029780، XM_006505364، NM_001356333، NM_001356334، XM_030255098، XM_030255099

RefSeq (پروتئین)

XP_011532276، XP_016862455، NP_001341618، NP_001341619، NP_001341620، NP_001341621، NP_001341622، NP_001341624، NP_001341623 NP_002871، XP_011532276، XP_016862455، NP_001341618، NP_001341619، NP_001341620، NP_001341621، NP_001341622، NP_001341624، NP_001341623

XP_006505427، NP_001343262، NP_001343263، XP_030110958، XP_030110959 NP_084056، XP_006505427، NP_001343262، NP_001343263، XP_030110958، XP_030110959

موقعیت (UCSC)ن/مChr : 115.6 – 115.65 Mb
جستجوی PubMed[۲][۳]
ویکی‌داده
مشاهده/ویرایش انسانمشاهده/ویرایش موش

پروتئین کیناز سرین/ترئونین پروتو-آنکوژن RAF proto-oncogene serine/threonine-protein kinase (انگلیسی: C-Raf) که با نام‌های «پروتو-آنکوژن c-RAF» یا به‌اختصار «c-Raf» و حتی «Raf-1» هم شناخته می‌شود، یک آنزیم است[۴] که در انسان توسط ژن «RAF1» کُد می‌شود.[۵][۶] این آنزیم بخشی از مسیر «پیام‌دهی MAPK/ERK» است و پایین‌دستِ زیرگروهِ Ras از جی‌تی‌پی‌آزهای وابسته‌به غشاء عمل می‌کند.[۷]

آنزیم c-Raf یکی از اعضای خانوادهٔ RAF کیناز از پروتئین کینازهای اختصاصی سرین/ترئونین است.

ژن «RAF1» بر روی کروموزوم ۳ واقع است. با آنکه پروتئین c-Raf در شرایط آزمایشگاهی قابلیت جهش به یک آنکوژن (ژن سرطان‌زا) را داشته و حتی در چند نوع تومور انسانی هم مشاهده شده،[۸][۹] اما همتای دیگرش «BRAF» نقش مهمتری در ایجاد سرطان در انسان ایفا می‌کند.[۱۰]

تصویر شماتیکی از ساختار c-Raf انسانی

جستارهای وابسته

منابع

  1. ↑ ۱٫۰ ۱٫۱ ۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000000441 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ Li P, Wood K, Mamon H, Haser W, Roberts T (February 1991). "Raf-1: a kinase currently without a cause but not lacking in effects". Cell. 64 (3): 479–82. doi:10.1016/0092-8674(91)90228-Q. PMID 1846778.
  5. ↑ Rapp UR, Goldsborough MD, Mark GE, Bonner TI, Groffen J, Reynolds FH, Stephenson JR (July 1983). "Structure and biological activity of v-raf, a unique oncogene transduced by a retrovirus". Proc. Natl. Acad. Sci. U.S.A. 80 (14): 4218–22. Bibcode:1983PNAS...80.4218R. doi:10.1073/pnas.80.14.4218. PMC 384008. PMID 6308607.
  6. ↑ Bonner T, O'Brien SJ, Nash WG, Rapp UR, Morton CC, Leder P (January 1984). "The human homologs of the raf (mil) oncogene are located on human chromosomes 3 and 4". Science. 223 (4631): 71–4. Bibcode:1984Sci...223...71B. doi:10.1126/science.6691137. PMID 6691137.
  7. ↑ "Entrez Gene: RAF1 v-raf-1 murine leukemia viral oncogene homolog 1".
  8. ↑ Storm SM, Rapp UR (April 1993). "Oncogene activation: c-raf-1 gene mutations in experimental and naturally occurring tumors". Toxicol. Lett. 67 (1–3): 201–10. doi:10.1016/0378-4274(93)90056-4. PMID 8451761.
  9. ↑ Zebisch A, Staber PB, Delavar A, Bodner C, Hiden K, Fischereder K, Janakiraman M, Linkesch W, Auner HW, Emberger W, Windpassinger C, Schimek MG, Hoefler G, Troppmair J, Sill H (April 2006). "Two transforming C-RAF germ-line mutations identified in patients with therapy-related acute myeloid leukemia". Cancer Res. 66 (7): 3401–8. doi:10.1158/0008-5472.CAN-05-0115. PMID 16585161.
  10. ↑ Emuss V, Garnett M, Mason C, Marais R (November 2005). "Mutations of C-RAF are rare in human cancer because C-RAF has a low basal kinase activity compared with B-RAF". Cancer Res. 65 (21): 9719–26. doi:10.1158/0008-5472.CAN-05-1683. PMID 16266992.

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