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url url url url
  2. Weltenzyklopädie
  3. گیرنده گابا A - ویکی‌پدیا، دانشنامهٔ آزاد
گیرنده گابا A - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد
ساختار گیرنده استیل‌کولین نیکوتینی (nAchR: پی‌دی‌بی 2BG9) که بسیار شبیه گیرنده GABAA است. بالا: نمای کناری از nAchR که درون غشاء سلولی قرار گرفته است. پایین: نمای گیرنده از قسمت برون‌سلولی غشاء.
تصویر شماتیک گیرنده GABAA. چپ: زیرواحد تک‌پاری GABAA که در دولایه لیپیدی (خط‌های زرد متصل به دایره‌های آبی) قرار گرفته است. چهار پیچه آلفا تراغشائی (۱-۴) به صورت سیلندرهایی نمایش داده شده‌اند. پیوند دی‌سولفیدی بین دامنه برون‌سلولی سرشاخه C که مشخصه خانواده گیرنده‌های حلقه-سیستینی (که شامل گیرنده GABAA هم می‌شود) است توسط خط زرد نمایش داده شده است. راست: پنج زیرواحد به طور متقارن حول حفره انتقال آنیون کلرید قرار گرفته‌اند. حلقه‌های برون‌سلولی برای وضوح بیش‌تر نمایش داده نشده‌اند.

گیرنده GABAA یکی از دو کانال یونی دریچه-لیگاندی مسئول برای انتقال اثر اسید آمینوبوتریک گاما (ترارسان عصبی بازدارنده اصلی در مغز) است. تحریک این گیرنده با افزایش ورود یون کلر منفی به داخل سلول تحریک‌پذیری نورونها را کم میکند. مصرف الکل و بنزودیازپین‌ها سیستم گاباآ (GABAA) را درگیر می‌کند.

جستارهای وابسته

منابع

مشارکت‌کنندگان ویکی‌پدیا. «GABAA receptor». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۵ اکتبر ۲۰۰۸.

آیکون خرد

این یک مقالهٔ خرد زیست‌شناسی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

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