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url url url url
  2. Weltenzyklopädie
  3. پروگابید - ویکی‌پدیا، دانشنامهٔ آزاد
پروگابید - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد
پروگابید
داده‌های بالینی
روش مصرف داروOral
کد ATC
وضعیت قانونی
وضعیت قانونی
  • Prescription only
داده‌های فارماکوکینتیک
زیست فراهمی60%
پیوند پروتئینی95%
متابولیسمکبد
نیمه‌عمر حذف4 hours
دفعکلیه
شناسه‌ها
  • 4-[(4-Chlorophenyl)-(5-fluoro-2-hydroxy-phenyl)-methylidene]aminobutanamide
شمارهٔ سی‌ای‌اس
پاب‌کم CID
دراگ‌بنک
کم‌اسپایدر
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.057.872 ویرایش در ویکی‌داده
داده‌های فیزیکی و شیمیایی
فرمول شیمیاییC17H16ClFN2O2
جرم مولی۳۳۴٫۷۸ g·mol−1
مدل سه بعدی (جی‌مول)
  • Clc1ccc(cc1)/C(=N\CCCC(N)=O)c2cc(F)ccc2O
  • InChI=1S/C17H16ClFN2O2/c18-12-5-3-11(4-6-12)17(21-9-1-2-16(20)23)14-10-13(19)7-8-15(14)22/h3-8,10,22H,1-2,9H2,(H2,20,23)/b21-17+ ✔Y
  • Key:IBALRBWGSVJPAP-HEHNFIMWSA-N ✔Y
  (صحت‌سنجی)

پروگابید (انگلیسی: Progabide) آنالوگ و پیش داروی γ-آمینوبوتیریک اسید (گابا) است که در درمان صرع به کار می‌رود. پروگابید از راه تبدیل به گابا به عنوان آگونیست گیرنده‌های GABAA، GABAB و GABAA-ρ عمل می‌کند.

کاربرد

پروگابید در فرانسه برای تک‌درمانی یا استفاده کمکی در درمان صرع تأیید شده است - به‌ویژه تشنج‌های تونیک-کلونیک، میوکلونیک، جزئی و سندرم لنوکس-گاستوت در کودکان و بزرگسالان.

پروگابید افزون بر صرع برای بسیاری از بیماری‌ها، از جمله بیماری پارکینسون، اسکیزوفرنی، افسردگی بالینی، اختلال اضطرابی و اسپاستیسیتی با سطوح مختلف موفقیت مورد بررسی قرار گرفته است.[۱]

جستارهای وابسته

منابع

  1. ↑ Bartholini G, Scatton B, Zivkovic B, Lloyd KG (1987). "GABA receptor agonists and extrapyramidal motor function: therapeutic implications for Parkinson's disease". Advances in Neurology. 45: 79–83. PMID 3030072.

پیوند به بیرون

در ویکی‌انبار پرونده‌هایی دربارهٔ پروگابید موجود است.
آیکون خرد

این یک مقالهٔ خرد داروشناسی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

Pusat Layanan

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