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url url url url
  2. Weltenzyklopädie
  3. ماروپیتانت - ویکی‌پدیا، دانشنامهٔ آزاد
ماروپیتانت - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد
ماروپیتانت
داده‌های بالینی
تلفظ‎/məˈrɒpɪtænt/‎ mə-ROP-i-tant
نام‌های تجاریCerenia, Prevomax, Vetemex
نام‌های دیگر(2S,3S)-2-Benzhydryl-N-(5-tert-butyl-2-methoxybenzyl) quinuclidin-3-amine، maropitant citrate (USAN US)
AHFS/Drugs.comInternational Drug Names
داده‌ها
روش مصرف داروOral, subcutaneous, Intravenous
گروه داروییAntiemetic
کد ATCvet
وضعیت قانونی
وضعیت قانونی
داده‌های فارماکوکینتیک
زیست فراهمیOral: 20–30% dogs, 50% cats
SQ: 90% (both)
پیوند پروتئینی99.5%
متابولیسمLiver (CYP3A12 and CYP2D15)
متابولیت‌هاCJ-18,518
نیمه‌عمر حذف6–8 hours (SQ)
مدت زمان اثر24 hours (SQ)
شناسه‌ها
  • (2S,3S)-N-(5-tert-Butyl-2-methoxybenzyl)-2-(diphenylmethyl)-1-azabicyclo[2.2.2]octan-3-amine
شمارهٔ سی‌ای‌اس
پاب‌کم CID
کم‌اسپایدر
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
داده‌های فیزیکی و شیمیایی
فرمول شیمیاییC32H40N2O
جرم مولی۴۶۸٫۶۸۵ g·mol−1
مدل سه بعدی (جی‌مول)
  • O=C(O)C(O)(CC(=O)O)CC(=O)O.O.O(c1ccc(cc1CN[C@@H]2[C@@H](N3CCC2CC3)C(c4ccccc4)c5ccccc5)C(C)(C)C)C
  • InChI=1S/C32H40N2O.C6H8O7.H2O/c1-32(2,3)27-15-16-28(35-4)26(21-27)22-33-30-25-17-19-34(20-18-25)31(30)29(23-11-7-5-8-12-23)24-13-9-6-10-14-24;7-3(8)1-6(13,5(11)12)2-4(9)10;/h5-16,21,25,29-31,33H,17-20,22H2,1-4H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);1H2/t30-,31-;;/m0../s1 ✔Y
  • Key:PGVSXRHFXJOMGW-YBZGWEFGSA-N ✔Y
  (صحت‌سنجی)

ماروپیتانت (انگلیسی: Maropitant) یک آنتاگونیست گیرنده نوروکینین-1 (NK1) است که برای درمان بیماری حرکت و استفراغ در حیوانات خانگی ایجاد شده است.[۱][۲] در سال ۲۰۰۷ توسط FDA برای استفاده در سگ‌ها و در سال ۲۰۱۲ برای گربه‌ها تأیید شد.[۳]

منابع

  1. ↑ "Cerenia (maropitant citrate) Injectable Solution, Dogs" (PDF). Food and Drug Administration. Retrieved 2011-04-19.
  2. ↑ Package Insert for Cerenia at Pfizer Animal Health (full detailed drug information)
  3. ↑ Riviere, Jim E.; Papich, Mark G. (2017). Veterinary Pharmacology and Therapeutics. John Wiley & Sons. p. 2828. ISBN 978-1-118-85588-1.

پیوند به بیرون

در ویکی‌انبار پرونده‌هایی دربارهٔ ماروپیتانت موجود است.
آیکون خرد

این یک مقالهٔ خرد داروشناسی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

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