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url url url url
  2. Weltenzyklopädie
  3. فنازوسین - ویکی‌پدیا، دانشنامهٔ آزاد
فنازوسین - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد
فنازوسین
داده‌های بالینی
نام‌های دیگرFenazocina, Phenazocinum, DEA No. 9715
روش مصرف داروخوراکی
کد ATC
وضعیت قانونی
وضعیت قانونی
شناسه‌ها
  • (2R,6R,11R)-6,11-Dimethyl-3-(2-phenylethyl)-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-8-ol
شمارهٔ سی‌ای‌اس
پاب‌کم CID
کم‌اسپایدر
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.004.397 ویرایش در ویکی‌داده
داده‌های فیزیکی و شیمیایی
فرمول شیمیاییC22H27NO۱
جرم مولی۳۲۱٫۴۶۴ g·mol−1
مدل سه بعدی (جی‌مول)
  • C[C@H]1[C@H]2Cc3ccc(cc3[C@@]1(CCN2CCc4ccccc4)C)O
  • InChI=1S/C22H27NO/c1-16-21-14-18-8-9-19(24)15-20(18)22(16,2)11-13-23(21)12-10-17-6-4-3-5-7-17/h3-9,15-16,21,24H,10-14H2,1-2H3/t16-,21+,22+/m0/s1 N
  • Key:ZQHYKVKNPWDQSL-KNXBSLHKSA-N N
 N✔Y (این چیست؟)  (صحت‌سنجی)

فنازوسین (انگلیسی: Phenazocine) (با نام‌های تجاری پرینادول، نارفن) یک داروی ضددرد اپیوئیدی است که مربوط به پنتازوسین است و نمایه‌ای از اثرات مشابه دارد.[۱]

اثرات فنازوسین شامل بی‌دردی و سرخوشی است، همچنین ممکن است شامل بدحالی و توهم در دوزهای بالا باشد که به احتمال زیاد به دلیل اثر در گیرنده‌های κ-اپیوئیدی و σ است.[۲]

به نظر می‌رسد فنازوسین یک مسکن بسیار قوی تر با عوارض جانبی کمتر نسبت به پنتازوسین است که احتمالاً به دلیل نسبت اتصال μ/κ مطلوب‌تر است. فنازوسین مسکن بسیار قوی‌تری نسبت به پنتازوسین و سایر داروهای سری بنزومورفان است که احتمالاً به دلیل وجود یک جایگزین N-فناتیل است که به افزایش فعالیت μ-اپیوئیدی در بسیاری از کلاس‌های مسکن‌های اپیوئیدی معروف است.[۳]


در نتیجه، فنازوسین چهار برابر مورفین به عنوان یک مسکن قدرت دارد. همچنین باعث اسپاسم اسفنکتر اودی نمی‌شود و آن را برای درمان درد صفراوی یا پانکراس مناسب‌تر از مورفین می‌کند.[۴]

منابع

  1. ↑ US 2959594, "Iso-benzmorphan derivatives" 
  2. ↑ Harris LS, Pierson AK (February 1964). "Some Narcotic Antagonists in the Benzomorphan Series". Journal of Pharmacology and Experimental Therapeutics. 143: 141–8. PMID 14163985.
  3. ↑ Feinberg AP, Creese I, Snyder SH (November 1976). "The opiate receptor: a model explaining structure-activity relationships of opiate agonists and antagonists". Proceedings of the National Academy of Sciences USA. 73 (11): 4215–9. Bibcode:1976PNAS...73.4215F. doi:10.1073/pnas.73.11.4215. PMC 431391. PMID 186791.
  4. ↑ Hopton D. (January 1971). "Double-blind clinical trial of the analgesic effects of phenazocine hydrobromide (Narphen) compared with morphine sulphate in patients with acute abdominal pain". Gut. 12 (1): 51–4. doi:10.1136/gut.12.1.51. PMC 1411461. PMID 4929685.

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