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url url url url
  2. Weltenzyklopädie
  3. تیلیدین - ویکی‌پدیا، دانشنامهٔ آزاد
تیلیدین - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد
Tilidine
داده‌های بالینی
نام‌های تجاریTilicomp, Tilitrate, Valoron, Vilidin
AHFS/Drugs.comInternational Drug Names
کد ATC
وضعیت قانونی
وضعیت قانونی
داده‌های فارماکوکینتیک
زیست فراهمی6% (parent compound), 99% (active metabolite)[۱]
متابولیسمMetabolised by the liver, mostly via the enzymes CYP3A4 and CYP2C19[۲]
نیمه‌عمر حذف3-5 hours[۲]
دفعUrine (90%)[۲]
شناسه‌ها
  • Ethyl (1R,2S; 1S, 2R)-2-(dimethylamino)-1-phenylcyclohex-3-ene-1-carboxylate
شمارهٔ سی‌ای‌اس
UNII
ChEBI
ChEMBL
ECHA InfoCard100.039.779 ویرایش در ویکی‌داده
داده‌های فیزیکی و شیمیایی
فرمول شیمیاییC17H23NO۲
جرم مولی۲۷۳٫۳۷ g·mol−1
مدل سه بعدی (جی‌مول)
  • O=C(OCC)[C@@]1(CCC=C[C@H]1N(C)C)C2=CC=CC=C2
 N✔Y (این چیست؟)  (صحت‌سنجی)

تیلیدین که با نام‌های تجاری والورون (Valoron) و والتران (Valtran) نیز شناخته می‌شود، یک مسکن اپیوئیدی صناعی است که به طور عمده در آلمان، سوئیس، شمال آفریقا و بلژیک برای تسکین دردهای حاد و مزمن متوسط تا شدید به کار می‌رود. مدت زمان لازم برای شروع اثر پس از مصرف خوراکی ۱۰ تا ۱۵ دقیقه بوده و حداکثر اثر آن پس از ۲۵ تا ۳۰ دقیقه ظاهر می‌شود.

کاربردهای بالینی

دردهای حاد و مزمن متوسط تا شدید

Tilidine

عوارض جانبی

تهوع، استفراغ، سبکی سر، گیجی، خستگی، سردرد و پرخاشگری. سایر عوارض با شیوع کمتر عبارتند از توهم، سرخوشی (یوفوریا), ترمور، هیپررفلکسی، اسهال و درد شکم

فارماکولوژی

این دارو جزء اپیوئیدهای با توان پایین تا متوسط است و توان تیلیدین خوراکی حدود ۰٫۲ است، به عبارتی ۱۰۰ میلی گرم تیلیدین معادل حدود ۲۰ میلی گرم مورفین است. این دارو از راه خوراکی، شیاف و تزریق وریدی، عضلانی یا زیرجلدی به طورت تک دوز ۵۰ تا ۱۰۰ میلی گرمی تجویز می‌شود. بیشینه دوز روزانه ۶۰۰ میلی گرم است.

روش تولید و ساختار شیمیایی

در این شکل طریقه تولید و ساختار تیلیدین نشان داده شده است:

منابع

در ویکی‌انبار پرونده‌هایی دربارهٔ تیلیدین موجود است.
  1. ↑ Vollmer, KO; Thomann, P; Hengy, H (October 1989). "Pharmacokinetics of tilidine and metabolites in man". Arzneimittel-Forschung. 39 (10): 1283–8. PMID 2610722.
  2. ↑ ۲٫۰ ۲٫۱ ۲٫۲ "Tilidin N Sandoz® DP Lösung zum Einnehmen" [Tilidin N Sandoz ® DP oral solution] (PDF) (به آلمانی). Wooden Churches: Sandoz Pharmaceuticals GmbH. December 2012. Archived from the original (PDF) on 2 May 2014. Retrieved 18 April 2014.

[۱]

  1. ↑ https://teknopedia.ac.id/wiki/Tilidine
Pusat Layanan

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