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url url url url
  2. Weltenzyklopädie
  3. زولی‌فلوداسین - ویکی‌پدیا، دانشنامهٔ آزاد
زولی‌فلوداسین - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد
زولی‌فلوداسین
داده‌های بالینی
نام‌های دیگرAZD0914; ETX0914
رده‌بندی داروهای
بارداری
  • Not classified yet
روش مصرف داروOral
گروه داروییآنتی‌بیوتیک
وضعیت قانونی
وضعیت قانونی
  • US: IND
  • Investigational
داده‌های فارماکوکینتیک
زیست فراهمی۹۷٫۸٪
متابولیسمکبد
اثر دارو
  • Fasted: 1.5–2.3 h
  • Fed: 4 h
نیمه‌عمر حذف5.3–6.3 h
دفع
شناسه‌ها
شمارهٔ سی‌ای‌اس
پاب‌کم CID
دراگ‌بنک
UNII
KEGG
داده‌های فیزیکی و شیمیایی
فرمول شیمیاییC۲۲H۲۲F۱N۵O۷
جرم مولی۴۸۷٫۴۴۴ g·mol−1
مدل سه بعدی (جی‌مول)
  • C[C@@H]1CN2[C@H]([C@@H](O1)C)C3(CC4=C2C(=C5C(=C4)C(=NO5)N6[C@H](COC6=O)C)F)C(=O)NC(=O)NC3=O
  • InChI=1S/C22H22FN5O7/c1-8-7-33-21(32)28(8)17-12-4-11-5-22(18(29)24-20(31)25-19(22)30)16-10(3)34-9(2)6-27(16)14(11)13(23)15(12)35-26-17/h4,8-10,16H,5-7H2,1-3H3,(H2,24,25,29,30,31)/t8-,9+,10-,16+/m0/s1
  • Key:ZSWMIFNWDQEXDT-ZESJGQACSA-N

زولی‌فلوداسین (انگلیسی: Zoliflodacin) یک آنتی بیوتیک آزمایشی است که برای درمان عفونت نایسریا گونوره (سوزاک) مورد مطالعه قرار گرفته است.[۱] این دارو یک مکانیسم جدید عمل دارد که شامل مهار توپوایزومرازهای باکتریایی نوع II است.[۲]

مکانیسم عمل

زولی‌فلوداسین علیه هر دو نوع باکتری گرم مثبت و منفی فعال است، اما در برابر باکتری‌های گرم منفی فعال‌تر است. این دارو با مهار DNA جیراز، آنزیمی که برای جداسازی DNA باکتری ضروری است، عمل می‌کند و در نتیجه تکثیر سلولی را مهار می‌کند.

منابع

  1. ↑ Taylor SN, Marrazzo J, Batteiger BE, Hook EW, Seña AC, Long J, et al. (November 2018). "Single-Dose Zoliflodacin (ETX0914) for Treatment of Urogenital Gonorrhea". The New England Journal of Medicine. 379 (19): 1835–1845. doi:10.1056/NEJMoa1706988. hdl:1805/19865. PMID 30403954.
  2. ↑ Basarab GS, Kern GH, McNulty J, Mueller JP, Lawrence K, Vishwanathan K, et al. (July 2015). "Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases". Scientific Reports. 5: 11827. Bibcode:2015NatSR...511827B. doi:10.1038/srep11827. PMC 4501059. PMID 26168713.
آیکون خرد

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