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url url url url
  2. Weltenzyklopädie
  3. دوکسورابیسین - ویکی‌پدیا، دانشنامهٔ آزاد
دوکسورابیسین - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد
دوکسورابیسین
داده‌های بالینی
نام‌های تجاریDoxil
AHFS/Drugs.commonograph
مدلاین پلاسa682221
رده‌بندی داروهای
بارداری
  • AU: D
روش مصرف داروIntravenous
کد ATC
وضعیت قانونی
وضعیت قانونی
داده‌های فارماکوکینتیک
زیست فراهمی5% (Oral)
متابولیسمCYP3A4
نیمه‌عمر حذف12–18.5 hours when released from liposomes[۱]
دفعBiliary and fecal
شناسه‌ها
  • (7S,9S)-7-[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,9,11-trihydroxy-9-(2-hydroxyacetyl)-4-methoxy-8,10-dihydro-7H-tetracene-5,12-dione
شمارهٔ سی‌ای‌اس
پاب‌کم CID
دراگ‌بنک
کم‌اسپایدر
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.041.344 ویرایش در ویکی‌داده
داده‌های فیزیکی و شیمیایی
فرمول شیمیاییC27H29NO۱۱
جرم مولی۵۴۳٫۵۲ g/mol g·mol−1
مدل سه بعدی (جی‌مول)
  • C[C@H]1[C@H]([C@H](C[C@@H](O1)O[C@H]2C[C@@](Cc3c2c(c4c(c3O)C(=O)c5cccc(c5C4=O)OC)O)(C(=O)CO)O)N)O
  • InChI=1S/C27H29NO11/c1-10-22(31)13(28)6-17(38-10)39-15-8-27 (36,16(30)9-29)7-12-19(15)26(35)21-20(24(12)33)23 (32)11-4-3-5-14(37-2)18(11)25(21)34/h3-5,10,13,15, 17,22,29,31,33,35-36H,6-9,28H2,1-2H3/t10-,13-,15-,17-,22+,27-/m0/s1 N
  • Key:AOJJSUZBOXZQNB-TZSSRYMLSA-N ✔Y
 N✔Y (این چیست؟)  (صحت‌سنجی)

دوکسورابیسین (به انگلیسی: Doxorubicin)

رده درمانی:داروهای درمان نئوپلاسم.

اشکال دارویی: آمپول

موارد مصرف

کاربرد اصلی این دارو شیمی درمانی سرطان‌های مختلف مانند بدخیمی‌های خونی، کارسینوما و سارکوم بافت نرم است.

عملکرد

دوکسورابیسین یک آنتی‌بیوتیک مؤثر در درمان سرطان از گروه آنتراسیکلینها می‌باشد.

عوارض جانبی

اصولاً داروهای شیمی درمانی پرعارضه اند و عارضه اصلی این دارو عوارض قلبی است.

جستارهای وابسته

نئوپلاسم

منابع

  1. ↑ Laginha, K.M. "Determination of Doxorubicin Levels in Whole Tumor and Tumor Nuclei in Murine Breast Cancer Tumors." Clinical Cancer Research. October 1, 2005. Vol. 11 (19). Retrieved on April 19, 2007.
  • فرهنگ داروهای ژنریک ایران، دکتر حشمتی، ۱۳۸۷
Pusat Layanan

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