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url url url url
  2. Weltenzyklopädie
  3. توپوتکان - ویکی‌پدیا، دانشنامهٔ آزاد
توپوتکان - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد
توپوتکان
داده‌های بالینی
نام‌های تجاریHycamtin, Potactasol
AHFS/Drugs.commonograph
مدلاین پلاسa610007
داده‌ها
رده‌بندی داروهای
بارداری
  • AU: D
روش مصرف داروتزریق وریدی, خوراکی (capsules)
کد ATC
وضعیت قانونی
وضعیت قانونی
داده‌های فارماکوکینتیک
زیست فراهمی31.4 % in humans[۱][۲]
پیوند پروتئینی35%
متابولیسمکبد
نیمه‌عمر حذف2–3 hours
دفعکلیه
شناسه‌ها
  • (S)-10-[(dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione monohydrochloride
شمارهٔ سی‌ای‌اس
پاب‌کم CID
IUPHAR/BPS
دراگ‌بنک
کم‌اسپایدر
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.213.372 ویرایش در ویکی‌داده
داده‌های فیزیکی و شیمیایی
فرمول شیمیاییC23H23N3O5
جرم مولی۴۲۱٫۴۵۳ g·mol−1
مدل سه بعدی (جی‌مول)
  • O=C\1N4\C(=C/C2=C/1COC(=O)[C@]2(O)CC)c3nc5c(cc3C4)c(c(O)cc5)CN(C)C
  • InChI=1S/C23H23N3O5/c1-4-23(30)16-8-18-20-12(9-26(18)21(28)15(16)11-31-22(23)29)7-13-14(10-25(2)3)19(27)6-5-17(13)24-20/h5-8,27,30H,4,9-11H2,1-3H3/t23-/m0/s1 ✔Y
  • Key:UCFGDBYHRUNTLO-QHCPKHFHSA-N ✔Y
 N✔Y (این چیست؟)  (صحت‌سنجی)

توپوتکان (انگلیسی: Topotecan) یک داروی شیمی درمانی و یک مهارکننده توپوایزومراز است. این دارو یک آنالوگ مصنوعی و محلول در آب از ترکیب شیمیایی طبیعی کامپتوتسین است. از آن به شکل نمک هیدروکلراید آن برای درمان سرطان تخمدان[۳]، سرطان ریه (کارسینوم سلول کوچک ریه/SCLC،[۴][۵] سرطان دهانه رحم[۶][۷] و سایر انواع سرطان استفاده می‌شود.

عوارض جانبی

  • سرکوب میلوسیتوپنی، به ویژه نوتروپنی، لکوپنی، کم خونی و ترومبوسیتوپنی
  • اسهال، تهوع، استفراغ، استوماتیت و یبوست
  • افزایش حساسیت به عفونت
  • آستنی


منابع

  1. ↑ Léger F, Loos WJ, Bugat R, Mathijssen RH, Goffinet M, Verweij J, et al. (December 2004). "Mechanism-based models for topotecan-induced neutropenia". Clinical Pharmacology and Therapeutics. 76 (6): 567–78. doi:10.1016/j.clpt.2004.08.008. PMID 15592328. S2CID 37527965.
  2. ↑ Gelderblom H, Loos WJ, Sissung TM, Burger H, Nooter K, Soepenberg O, et al. (July 2004). "Effect of ABCG2 genotype and mRNA expression on the bioavailability of topotecan". Journal of Clinical Oncology. 22 (14 suppl): 2015. doi:10.1200/jco.2004.22.90140.2015. PMID 28015603.
  3. ↑ "FDA Approves Ovaerian Cancer Drug". U.S. Food and Drug Administration. 29 May 1996. Archived from the original on January 19, 2009.
  4. ↑ "Oral Topotecan FDA Approved in US for Second Line SCLC". Onc Talk. Archived from the original on June 26, 2009. Retrieved February 7, 2009.
  5. ↑ "GSK Receives Approval for Hycamtin (topotecan) Capsules for theTreatment of Relapsed Small Cell Lung Cancer".
  6. ↑ "FDA Approval for Topotecan Hydrochloride". National Cancer Institute. Archived from the original on 2015-04-06. Retrieved 2009-02-07.
  7. ↑ "FDA approves topotecan hydrochloride (hycamtin) in combination with cisplatin for the treatment of Stage IVB recurrent or persistent carcinoma of the cervix". FDA/Center for Drug Evaluation and Research. Archived from the original on November 7, 2008. Retrieved February 7, 2009.

پیوند به بیرون

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