MAPKAPK2

MAPKAPK2
ساختارهای موجود
PDB	جستجوی هم‌ساخت‌شناسی: PDBe RCSB
فهرست شناسه‌های PDB
	1KWP, 1NXK, 1NY3, 2JBO, 2JBP, 2OKR, 2ONL, 2OZA, 2P3G, 2PZY, 3A2C, 3FPM, 3FYJ, 3FYK, 3GOK, 3KA0, 3KC3, 3KGA, 3M2W, 3M42, 3R2B, 3R2Y, 3R30, 3WI6, 4TYH
معین‌کننده‌ها
نام‌های دیگر	MAPKAPK2, MAPKAP-K2, MK-2, MK2, mitogen-activated protein kinase-activated protein kinase 2, MAPK activated protein kinase 2
شناسه‌های بیرونی	OMIM: 602006 MGI: 109298 HomoloGene: 56412 GeneCards: MAPKAPK2
موقعیت ژن (موش)
کروموزوم	کروموزوم ۱ (موش)
پایان	131,025,563 bp
الگوی گسترش RNA
	; ; ; ;
	More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی	• calmodulin-dependent protein kinase activity; • signal transducer activity; • nucleotide binding; • transferase activity; • kinase activity; • calcium-dependent protein serine/threonine kinase activity; • calmodulin binding; • ATP binding; • GO:0001948، GO:0016582 پیوند پروتئینی; • protein kinase activity; • protein serine/threonine kinase activity; • mitogen-activated protein kinase binding;
ترکیبات سلولی	• extracellular exosome; • سیتوزول; • میان‌تن; • نوکلئوپلاسم; • سیتوپلاسم; • هسته یاخته;
فرایند زیستی	• response to stress; • MAPK cascade; • regulation of mRNA stability; • response to cytokine; • GO:0035404 peptidyl-serine phosphorylation; • cellular response to vascular endothelial growth factor stimulus; • mRNA stabilization; • protein autophosphorylation; • 3'-UTR-mediated mRNA stabilization; • cellular response to DNA damage stimulus; • inner ear development; • p38MAPK cascade; • Ras protein signal transduction; • leukotriene metabolic process; • regulation of cellular response to heat; • فسفرگیری; • protein phosphorylation; • regulation of interleukin-6 production; • vascular endothelial growth factor receptor signaling pathway; • response to lipopolysaccharide; • inflammatory response; • macropinocytosis; • regulation of tumor necrosis factor production; • toll-like receptor signaling pathway; • GO:0007243 intracellular signal transduction;
	منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
	9261
	17164
	ENSG00000162889
	ENSMUSG00000016528
	P49137
	P49138
	NM_004759، NM_032960، XM_017002810، XM_047434418 XM_005273353، NM_004759، NM_032960، XM_017002810، XM_047434418
	NM_008551
	NP_116584، XP_005273410، XP_016858299 NP_004750، NP_116584، XP_005273410، XP_016858299
	NP_032577
	ویکی‌داده
مشاهده/ویرایش انسان	مشاهده/ویرایش موش

پروتئین کیناز ۲ فعال شده توسط MAP کیناز (انگلیسی: MAPKAPK2) یک پروتئین است که در انسان توسط ژن «MAPKAPK2» کُدگذاری می‌شود و جزئی از خانوادهٔ پروتئین کیناز اختصاصی سرین/ترئونین است.^[۴]^[۵]^[۶]

این پروتئین یکی از میانجی‌های آغاز فعالیت فاکتورهای فنوتیپ ترشحی مرتبط با پیری (SASP) توسط MTOR است.^[۷]^[۸] فعالیت MTOR سطح اینترلوکین ۱ آلفا را افزایش می‌دهد و اینکار با واسطهٔ MAPKAPK2 انجام می‌شود.^[۹]

منابع

↑ ^۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000016528 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Zu YL, Wu F, Gilchrist A, Ai Y, Labadia ME, Huang CK (April 1994). "The primary structure of a human MAP kinase activated protein kinase 2". Biochemical and Biophysical Research Communications. 200 (2): 1118–24. doi:10.1006/bbrc.1994.1566. PMID 8179591.
↑ Stokoe D, Caudwell B, Cohen PT, Cohen P (December 1993). "The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2". The Biochemical Journal. 296 ( Pt 3) (Pt 3): 843–9. doi:10.1042/bj2960843. PMC 1137771. PMID 8280084.
↑ Liu T, Warburton RR, Hill NS, Kayyali US (August 2015). "Anthrax lethal toxin-induced lung injury and treatment by activating MK2". Journal of Applied Physiology. 119 (4): 412–9. doi:10.1152/japplphysiol.00335.2015. PMC 4538279. PMID 26066827.
↑ Yessenkyzy A, Saliev T, Zhanaliyeva M, Masoud AR, Umbayev B, Sergazy S, et al. (May 2020). "Polyphenols as Caloric-Restriction Mimetics and Autophagy Inducers in Aging Research". Nutrients. 12 (5): 1344. doi:10.3390/nu12051344. PMC 7285205. PMID 32397145.
↑ Papadopoli D, Boulay K, Kazak L, Pollak M, Mallette F, Topisirovic I, Hulea L (2019). "mTOR as a central regulator of lifespan and aging". F1000Research. 8: 998. doi:10.12688/f1000research.17196.1. PMC 6611156. PMID 31316753.
↑ Laberge RM, Sun Y, Orjalo AV, Patil CK, Freund A, Zhou L, et al. (August 2015). "MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation". Nature Cell Biology. 17 (8): 1049–61. doi:10.1038/ncb3195. PMC 4691706. PMID 26147250.

مشارکت‌کنندگان ویکی‌پدیا. «MAPKAPK2». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۴ اکتبر ۲۰۲۲.

برای مطالعهٔ بیشتر

Kapopara PR, von Felden J, Soehnlein O, Wang Y, Napp LC, Sonnenschein K, et al. (December 2014). "Deficiency of MAPK-activated protein kinase 2 (MK2) prevents adverse remodelling and promotes endothelial healing after arterial injury". Thrombosis and Haemostasis. 112 (6): 1264–76. doi:10.1160/TH14-02-0174. PMID 25120198.
Ben-Levy R, Hooper S, Wilson R, Paterson HF, Marshall CJ (September 1998). "Nuclear export of the stress-activated protein kinase p38 mediated by its substrate MAPKAP kinase-2". Current Biology. 8 (19): 1049–57. doi:10.1016/S0960-9822(98)70442-7. PMID 9768359. S2CID 15627349.
Stokoe D, Engel K, Campbell DG, Cohen P, Gaestel M (November 1992). "Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins". FEBS Letters. 313 (3): 307–13. doi:10.1016/0014-5793(92)81216-9. PMID 1332886.
Vulliet PR, Woodgett JR, Cohen P (November 1984). "Phosphorylation of tyrosine hydroxylase by calmodulin-dependent multiprotein kinase". The Journal of Biological Chemistry. 259 (22): 13680–3. doi:10.1016/S0021-9258(18)89798-8. PMID 6150037.
Engel K, Schultz H, Martin F, Kotlyarov A, Plath K, Hahn M, et al. (November 1995). "Constitutive activation of mitogen-activated protein kinase-activated protein kinase 2 by mutation of phosphorylation sites and an A-helix motif". The Journal of Biological Chemistry. 270 (45): 27213–21. doi:10.1074/jbc.270.45.27213. PMID 7592979.
Lavoie JN, Lambert H, Hickey E, Weber LA, Landry J (January 1995). "Modulation of cellular thermoresistance and actin filament stability accompanies phosphorylation-induced changes in the oligomeric structure of heat shock protein 27". Molecular and Cellular Biology. 15 (1): 505–16. doi:10.1128/MCB.15.1.505. PMC 232001. PMID 7799959.
Sutherland C, Alterio J, Campbell DG, Le Bourdellès B, Mallet J, Haavik J, Cohen P (October 1993). "Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen-activated protein (MAP) kinase and MAP-kinase-activated kinases 1 and 2". European Journal of Biochemistry. 217 (2): 715–22. doi:10.1111/j.1432-1033.1993.tb18297.x. PMID 7901013.
Knauf U, Jakob U, Engel K, Buchner J, Gaestel M (January 1994). "Stress- and mitogen-induced phosphorylation of the small heat shock protein Hsp25 by MAPKAP kinase 2 is not essential for chaperone properties and cellular thermoresistance". The EMBO Journal. 13 (1): 54–60. doi:10.1002/j.1460-2075.1994.tb06234.x. PMC 394778. PMID 7905823.
Freshney NW, Rawlinson L, Guesdon F, Jones E, Cowley S, Hsuan J, Saklatvala J (September 1994). "Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27". Cell. 78 (6): 1039–49. doi:10.1016/0092-8674(94)90278-X. PMID 7923354. S2CID 37608621.
Rivera VM, Miranti CK, Misra RP, Ginty DD, Chen RH, Blenis J, Greenberg ME (October 1993). "A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity". Molecular and Cellular Biology. 13 (10): 6260–73. doi:10.1128/mcb.13.10.6260. PMC 364685. PMID 8413226.
Beyaert R, Cuenda A, Vanden Berghe W, Plaisance S, Lee JC, Haegeman G, et al. (April 1996). "The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis response to tumor necrosis factor". The EMBO Journal. 15 (8): 1914–23. doi:10.1002/j.1460-2075.1996.tb00542.x. PMC 450110. PMID 8617238.
Ben-Levy R, Leighton IA, Doza YN, Attwood P, Morrice N, Marshall CJ, Cohen P (December 1995). "Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2". The EMBO Journal. 14 (23): 5920–30. doi:10.1002/j.1460-2075.1995.tb00280.x. PMC 394711. PMID 8846784.
Tan Y, Rouse J, Zhang A, Cariati S, Cohen P, Comb MJ (September 1996). "FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2". The EMBO Journal. 15 (17): 4629–42. doi:10.1002/j.1460-2075.1996.tb00840.x. PMC 452194. PMID 8887554.
Huang CK, Zhan L, Ai Y, Jongstra J (January 1997). "LSP1 is the major substrate for mitogen-activated protein kinase-activated protein kinase 2 in human neutrophils". The Journal of Biological Chemistry. 272 (1): 17–9. doi:10.1074/jbc.272.1.17. PMID 8995217.
Krump E, Sanghera JS, Pelech SL, Furuya W, Grinstein S (January 1997). "Chemotactic peptide N-formyl-met-leu-phe activation of p38 mitogen-activated protein kinase (MAPK) and MAPK-activated protein kinase-2 in human neutrophils". The Journal of Biological Chemistry. 272 (2): 937–44. doi:10.1074/jbc.272.2.937. PMID 8995385.
Engel K, Kotlyarov A, Gaestel M (June 1998). "Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation". The EMBO Journal. 17 (12): 3363–71. doi:10.1093/emboj/17.12.3363. PMC 1170674. PMID 9628873.
Craxton A, Shu G, Graves JD, Saklatvala J, Krebs EG, Clark EA (October 1998). "p38 MAPK is required for CD40-induced gene expression and proliferation in B lymphocytes". Journal of Immunology. 161 (7): 3225–36. PMID 9759836.
Heidenreich O, Neininger A, Schratt G, Zinck R, Cahill MA, Engel K, et al. (May 1999). "MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo". The Journal of Biological Chemistry. 274 (20): 14434–43. doi:10.1074/jbc.274.20.14434. PMID 10318869.

این یک مقالهٔ خرد آنزیم ، پروتئین یا زیست‌مولکول است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

[refGRCm38Ensembl-1] ۱٫۰ ^۱٫۱ ^۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000016528 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8179591-4] Zu YL, Wu F, Gilchrist A, Ai Y, Labadia ME, Huang CK (April 1994). "The primary structure of a human MAP kinase activated protein kinase 2". Biochemical and Biophysical Research Communications. 200 (2): 1118–24. doi:10.1006/bbrc.1994.1566. PMID 8179591.

[pmid8280084-5] Stokoe D, Caudwell B, Cohen PT, Cohen P (December 1993). "The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2". The Biochemical Journal. 296 ( Pt 3) (Pt 3): 843–9. doi:10.1042/bj2960843. PMC 1137771. PMID 8280084.

[Liu_412–419-6] Liu T, Warburton RR, Hill NS, Kayyali US (August 2015). "Anthrax lethal toxin-induced lung injury and treatment by activating MK2". Journal of Applied Physiology. 119 (4): 412–9. doi:10.1152/japplphysiol.00335.2015. PMC 4538279. PMID 26066827.

[pmid32397145-7] Yessenkyzy A, Saliev T, Zhanaliyeva M, Masoud AR, Umbayev B, Sergazy S, et al. (May 2020). "Polyphenols as Caloric-Restriction Mimetics and Autophagy Inducers in Aging Research". Nutrients. 12 (5): 1344. doi:10.3390/nu12051344. PMC 7285205. PMID 32397145.

[pmid31316753-8] Papadopoli D, Boulay K, Kazak L, Pollak M, Mallette F, Topisirovic I, Hulea L (2019). "mTOR as a central regulator of lifespan and aging". F1000Research. 8: 998. doi:10.12688/f1000research.17196.1. PMC 6611156. PMID 31316753.

[pmid26147250-9] Laberge RM, Sun Y, Orjalo AV, Patil CK, Freund A, Zhou L, et al. (August 2015). "MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation". Nature Cell Biology. 17 (8): 1049–61. doi:10.1038/ncb3195. PMC 4691706. PMID 26147250.

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ن ب و آنزیم‌ها
فعالیت	جایگاه فعال جایگاه اتصال سه‌گانه کاتالیزگر Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme کوآنزیم کوفاکتور کاتالیز آنزیم
قواعد	دگرریختاری Cooperativity بازدارنده آنزیم فعال‌کننده آنزیم
دسته‌بندی	عدد گروه آنزیم ابرخانواده آنزیم خانواده آنزیم فهرست آنزیم‌ها
سینتیک	سینتیک میکائلیس–منتن طرح ادی هوفستی طرح لاینویور برک طرح هانس وولف
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