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url url
  2. Weltenzyklopädie
  3. گیرنده ۱ اف سروتونین
گیرنده ۱ اف سروتونین
از ویکی‌پدیا، دانشنامهٔ آزاد
HTR1F
معین‌کننده‌ها
نام‌های دیگرHTR1F, 5-HT-1F, 5-HT1F, 5HT6, HTR1EL, MR77, 5-HT1F receptor, 5-hydroxytryptamine receptor 1F
شناسه‌های بیرونیOMIM: 182134 MGI: 99842 HomoloGene: 37361 GeneCards: HTR1F
هم‌ساخت‌شناسی
گونه‌هاانسانموش
Entrez

3355

15557

آنسامبل

ENSG00000179097

ENSMUSG00000050783

یونی‌پروت

P30939

Q02284

RefSeq (mRNA)

XM_005264751، XM_011533664، NM_001322208، NM_001322209، NM_001322210 NM_000866، XM_005264751، XM_011533664، NM_001322208، NM_001322209، NM_001322210

NM_008310

RefSeq (پروتئین)

NP_001309137، NP_001309138، NP_001309139، XP_005264808، XP_011531966 NP_000857، NP_001309137، NP_001309138، NP_001309139، XP_005264808، XP_011531966

NP_032336

موقعیت (UCSC)ن/مChr : 64.75 – 64.93 Mb
جستجوی PubMed[۲][۳]
ویکی‌داده
مشاهده/ویرایش انسانمشاهده/ویرایش موش

گیرنده ۱ اف سروتونین (انگلیسی: 5-HT1F receptor) یکی از انواع گیرنده‌های ۱ سروتونین است که در انسان توسط ژن «HTR1F» کُدگذاری می‌شود.[۴][۵][۶][۷][۸]

از آگونیستهای این گیرنده می‌توان به ال‌وای-۳۳۴٬۳۷۰[۹] و بنزآمید[۱۰] و از آنتاگونیست‌های آن می‌توان به مادهٔ شیمیایی «MLS000756415»[۱۱] اشاره کرد.

منابع

[ویرایش]
  1. ↑ ۱٫۰ ۱٫۱ ۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000050783 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Entrez Gene: HTR1F 5-hydroxytryptamine (serotonin) receptor 1F".
  5. ↑ Adham N, Kao HT, Schecter LE, Bard J, Olsen M, Urquhart D, Durkin M, Hartig PR, Weinshank RL, Branchek TA (Jan 1993). "Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase". Proceedings of the National Academy of Sciences of the United States of America. 90 (2): 408–12. Bibcode:1993PNAS...90..408A. doi:10.1073/pnas.90.2.408. PMC 45671. PMID 8380639.
  6. ↑ Lovenberg TW, Erlander MG, Baron BM, Racke M, Slone AL, Siegel BW, Craft CM, Burns JE, Danielson PE, Sutcliffe JG (Mar 1993). "Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes". Proceedings of the National Academy of Sciences of the United States of America. 90 (6): 2184–8. Bibcode:1993PNAS...90.2184L. doi:10.1073/pnas.90.6.2184. PMC 46050. PMID 8384716.
  7. ↑ Erdmann J, Shimron-Abarbanell D, Shridhar V, Smith DI, Propping P, Nöthen MM (1997). "Assignment of the human serotonin 1F receptor gene (HTR1F) to the short arm of chromosome 3 (3p13-p14.1)". Molecular Membrane Biology. 14 (3): 133–5. doi:10.3109/09687689709048173. PMID 9394293.
  8. ↑ Maassen VanDenBrink A, Vergouwe MN, Ophoff RA, Naylor SL, Dauwerse HG, Saxena PR, Ferrari MD, Frants RR (Jun 1998). "Chromosomal localization of the 5-HT1F receptor gene: no evidence for involvement in response to sumatriptan in migraine patients". American Journal of Medical Genetics. 77 (5): 415–20. doi:10.1002/(SICI)1096-8628(19980605)77:5<415::AID-AJMG12>3.0.CO;2-L. PMID 9632173.
  9. ↑ Wainscott DB, Krushinski JH, Audia JE, Schaus JM, Zgombick JM, Lucaites VL, Nelson DL (Mar 2005). "[3H]LY334370, a novel radioligand for the 5-HT1F receptor. I. In vitro characterization of binding properties". Naunyn-Schmiedeberg's Archives of Pharmacology. 371 (3): 169–77. doi:10.1007/s00210-005-1035-9. PMID 15900510. S2CID 2230855.
  10. ↑ Zhang D, Kohlman D, Krushinski J, Liang S, Ying BP, Reilly JE, Dinn SR, Wainscott DB, Nutter S, Gough W, Nelson DL, Schaus JM, Xu YC (Dec 2004). "Design, synthesis and evaluation of bicyclic benzamides as novel 5-HT1F receptor agonists". Bioorganic & Medicinal Chemistry Letters. 14 (24): 6011–6. doi:10.1016/j.bmcl.2004.09.079. PMID 15546719.
  11. ↑ PudChem: MLS000756415

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[ویرایش]

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[ویرایش]
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