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url url
  2. Weltenzyklopädie
  3. کاتپسین
کاتپسین
از ویکی‌پدیا، دانشنامهٔ آزاد
کاتپسین
ساختار کاتپسین K
شناسه‌ها
نمادCTP
پی‌فمPF00112
پی‌فم clanCL0125
اینترپروIPR000668
SMARTPept_C1
PROSITEPDOC00126
MEROPSC1
SCOPe1aec / SUPFAM

کاتپسین (انگلیسی: Cathepsin) گروهی از آنزیم‌های پروتئاز هستند که پروتئین‌ها را تجزیه می‌کنند و در بسیاری از جانداران دیده می‌شوند. در زبان یونانی باستان kata به معنای نزول یا پائین و hepsein به معنای جوشاندن یا آب‌پز کردن است. این خانوادهٔ آنزیمی چندین عضو دارد که به‌واسطهٔ ساختار، نحوهٔ عملکرد و مادهٔ هدف، از هم تمیز داده می‌شوند. بیشتر اعضای این خانواده در شرایط اسیدی (پی‌اچ پائین) که در لیزوزوم‌ها مهیاست، فعال می‌شوند و در نتیجه، فقط داخل این اندامک‌ها (که چنینی شرایط اسیدی دارند) فعالیت دارند. تنها استثنای این قاعده، کاتپسین K است که در فضای خارج‌سلولی بدنبال ترشح از استئوکلاست‌ها فعالیت می‌کند. این خانوادهٔ آنزیمی نقش مهمی در عملکرد و تغییروتحولِ سلولی ایفا می‌کنند.

انواع

[ویرایش]

اهمیت بالینی

[ویرایش]

منابع

[ویرایش]
  1. ↑ Nomura T, Katunuma N (February 2005). "Involvement of cathepsins in the invasion, metastasis and proliferation of cancer cells" (PDF). J. Med. Invest. 52 (1–2): 1–9. doi:10.2152/jmi.52.1. PMID 15751268.
  2. ↑ Lipton P (October 1999). "Ischemic cell death in brain neurons". Physiol. Rev. 79 (4): 1431–568. PMID 10508238.
  3. ↑ Yamashima T (2013). "Reconsider Alzheimer's disease by the 'calpain-cathepsin hypothesis'--a perspective review". PROGRESS IN NEUROLOGY. 105: 1–23. doi:10.1016/j.pneurobio.2013.02.004. PMID 23499711.
  4. ↑ Raptis SZ, Shapiro SD, Simmons PM, Cheng AM, Pham CT (June 2005). "Serine protease cathepsin G regulates adhesion-dependent neutrophil effector functions by modulating integrin clustering". Immunity. 22 (6): 679–91. doi:10.1016/j.immuni.2005.03.015. PMID 15963783.
  5. ↑ Chandran K (2005). "Endosomal Proteolysis of the Ebola Virus Glycoprotein Is Necessary for Infection". Science. 308: 1643–1645. doi:10.1126/science.1110656. PMC 4797943. PMID 15831716.
  6. ↑ Im E, Kazlauskas A (March 2007). "The role of cathepsins in ocular physiology and pathology". Exp. Eye Res. 84 (3): 383–8. doi:10.1016/j.exer.2006.05.017. PMID 16893541.

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[ویرایش]
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