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url url
  2. Weltenzyklopädie
  3. هیدروکسیلازهای وابسته به آلفا-کتوگلوتارات - ویکی‌پدیا، دانشنامهٔ آزاد
هیدروکسیلازهای وابسته به آلفا-کتوگلوتارات - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد

هیدروکسیلازهای وابسته به آلفا کتوگلوتارات (به انگلیسی: Alpha-ketoglutarate-dependent hydroxylases) یک کلاس اصلی از پروتئین‌های آهن غیرهم هستند که طیف وسیعی از واکنش‌ها را کاتالیز می‌کنند. این واکنش‌ها شامل واکنش‌های هیدروکسیلاسیون، دمتیلاسیون، انبساط حلقه، بسته شدن حلقه و غیراشباع شدن است.[۱][۲] از نظر عملکردی، هیدروکسیلازهای وابسته به αKG با آنزیم‌های سیتوکروم P450 قابل مقایسه هستند. هر دو از O۲ و اکی‌والان‌های کاهنده به عنوان کوسوبسترا استفاده می‌کنند و هر دو آب تولید می‌کنند.[۳]

جهت مطالعه

  • Martinez, Salette; Hausinger, Robert P. (2015-08-21). "Catalytic Mechanisms of Fe(II)- and 2-Oxoglutarate-dependent Oxygenases". The Journal of Biological Chemistry. 290 (34): 20702–20711. doi:10.1074/jbc.R115.648691. ISSN 0021-9258. PMC 4543632. PMID 26152721.
  • Hegg EL, Que L Jr (December 1997). "The 2-His-1-carboxylate facial triad--an emerging structural motif in mononuclear non-heme iron(II) enzymes". Eur. J. Biochem. 250 (3): 625–629. doi:10.1111/j.1432-1033.1997.t01-1-00625.x. PMID 9461283..
  • Myllylä R, Tuderman L, Kivirikko KI (November 1977). "Mechanism of the prolyl hydroxylase reaction. 2. Kinetic analysis of the reaction sequence". Eur. J. Biochem. 80 (2): 349–357. doi:10.1111/j.1432-1033.1977.tb11889.x. PMID 200425.
  • Valegård K, Terwisscha van Scheltinga AC, Dubus A, Ranghino G, Oster LM, Hajdu J, Andersson I (January 2004). "The structural basis of cephalosporin formation in a mononuclear ferrous enzyme" (PDF). Nat. Struct. Mol. Biol. 11 (1): 95–101. doi:10.1038/nsmb712. PMID 14718929.
  • Price JC, Barr EW, Tirupati B, Bollinger JM Jr, Krebs C (June 2003). "The first direct characterization of a high-valent iron intermediate in the reaction of an alpha-ketoglutarate-dependent dioxygenase: a high-spin FeIV complex in taurine/alpha-ketoglutarate dioxygenase (TauD) from Escherichia coli". Biochemistry. 42 (24): 7497–7508. doi:10.1021/bi030011f. PMID 12809506.
  • Proshlyakov DA, Henshaw TF, Monterosso GR, Ryle MJ, Hausinger RP (February 2004). "Direct detection of oxygen intermediates in the non-heme Fe enzyme taurine/alpha-ketoglutarate dioxygenase". J. Am. Chem. Soc. 126 (4): 1022–1023. doi:10.1021/ja039113j. PMID 14746461.
  • Hewitson KS, Granatino N, Welford RW, McDonough MA, Schofield CJ (April 2005). "Oxidation by 2-oxoglutarate oxygenases: non-haem iron systems in catalysis and signalling". Phil. Trans. R. Soc. A. 363 (1829): 807–828. Bibcode:2005RSPTA.363..807H. doi:10.1098/rsta.2004.1540. PMID 15901537.
  • Wick CR, Lanig H, Jäger CM, Burzlaff N, Clark T (November 2012). "Structural Insight into the Prolyl Hydroxylase PHD2: A Molecular Dynamics and DFT Study". Eur. J. Inorg. Chem. 2012 (31): 4973–4985. doi:10.1002/ejic.201200391.

منابع

  1. ↑ Flashman E, Schofield CJ (February 2007). "The most versatile of all reactive intermediates?". Nat. Chem. Biol. 3 (2): 86–87. doi:10.1038/nchembio0207-86. PMID 17235343.
  2. ↑ Hausinger RP (January–February 2004). "Fe(II)/α-ketoglutarate-dependent hydroxylases and related enzymes". Crit. Rev. Biochem. Mol. Biol. 39 (1): 21–68. doi:10.1080/10409230490440541. PMID 15121720.
  3. ↑ Solomon EI, Decker A, Lehnert N (April 2003). "Non-heme iron enzymes: contrasts to heme catalysis". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 3589–3594. doi:10.1073/pnas.0336792100. PMC 152966. PMID 12598659.
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