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url url
  2. Weltenzyklopädie
  3. لکانمب - ویکی‌پدیا، دانشنامهٔ آزاد
لکانمب - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد
لکانمب
پادتن مونوکلونال
گونهWhole antibody
منبعHumanized
هدفآمیلوئید بتا
داده‌های بالینی
کد ATC
  • None
وضعیت قانونی
وضعیت قانونی
  • Investigational
شناسه‌ها
شمارهٔ سی‌ای‌اس
کم‌اسپایدر
  • none
UNII

لکانِـمَب (انگلیسی: Lecanemab) یک آنتی‌بادی مونوکلونال است که برای درمان بیماری آلزایمر استفاده می‌شود.[۱][۲] و محصول مشترک بایوژن و ایزای است. این دارو آنتی بادی محرک-آمیلوئید بتا است.[۳]

این مادهٔ شیمیایی، نمونهٔ انسانی‌شده[۴] از پادتن mAb158 موش است که پیش‌سازهای فیبریل را شناسایی کرده و در مدل‌های حیوانی از رسوب آمیلوئید بتا که ایجادکنندهٔ آلزایمر است، جلوگیری نموده‌است.[۵]

در سپتامبر ۲۰۲۲ بایوژن اعلام کرد[۶][۷] نتایج یک کارآزمایی بالینی فاز ۳ برای متوقف کردن روند بیماری آلزایمر مثبت بوده است.[۸]

منابع

  1. ↑ "FDA Grants Accelerated Approval for Alzheimer's Disease Treatment" (Press release). U.S. Food and Drug Administration (FDA). 6 January 2023. Archived from the original on 7 January 2023. Retrieved 7 January 2023. مالکیت عمومی This article incorporates text from this source, which is in the public domain.
  2. ↑ ClinicalTrials.gov NCT01767311 Study to Evaluate Safety, Tolerability, and Efficacy of BAN2401 in Subjects With Early Alzheimer's Disease
  3. ↑ «DailyMed - LEQEMBI- lecanemab injection, solution». dailymed.nlm.nih.gov. دریافت‌شده در ۲۰۲۳-۰۸-۰۱.
  4. ↑ Lannfelt L, Möller C, Basun H, Osswald G, Sehlin D, Satlin A, Logovinsky V, Gellerfors P (2014). "Perspectives on future Alzheimer therapies: amyloid-β protofibrils - a new target for immunotherapy with BAN2401 in Alzheimer's disease". Alzheimer's Research & Therapy. 6 (2): 16. doi:10.1186/alzrt246. PMC 4054967. PMID 25031633.
  5. ↑ Söllvander S, Nikitidou E, Gallasch L, Zyśk M, Söderberg L, Sehlin D, Lannfelt L, Erlandsson A (March 2018). "The Aβ protofibril selective antibody mAb158 prevents accumulation of Aβ in astrocytes and rescues neurons from Aβ-induced cell death". Journal of Neuroinflammation. 15 (1): 98. doi:10.1186/s12974-018-1134-4. PMC 5875007. PMID 29592816.
  6. ↑ "Lecanemab Confirmatory Phase 3 Clarity Ad Study Met Primary Endpoint, Showing Highly Statistically Significant Reduction of Clinical Decline in Large Global Clinical Study of 1,795 Participants With Early Alzheimer's Disease". Biogen. September 27, 2022. Archived from the original on 27 September 2022. Retrieved September 28, 2022.
  7. ↑ Robbins R, Belluck P (September 27, 2022). "Alzheimer's Drug Slows Cognitive Decline in Key Study". New York Times. Retrieved September 28, 2022.
  8. ↑ "A Study to Confirm Safety and Efficacy of Lecanemab in Participants With Early Alzheimer's Disease (Clarity AD)". ClinicalTrials.gov. 11 July 2022. Retrieved September 28, 2022.
آیکون خرد

این یک مقالهٔ خرد پیرامون دارو یا داروشناسی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

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