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url url
  2. Weltenzyklopädie
  3. لنتینان - ویکی‌پدیا، دانشنامهٔ آزاد
لنتینان - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد
لنتینان
داده‌های بالینی
نام‌های دیگر(2S,3R,4S,5S,6R)-2-[(2S,3R,4S,5R,6R)-2-[(2S,3R,4S,5R,6R)-2-[(2R,3R,4S,5R,6S)-3,5-dihydroxy-2-(hydroxymethyl)-6-[(2R,3R,4S,5R,6R)-2,3,5-trihydroxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-4-yl]oxyoxan-4-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,5-dihydroxy-6-[[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxymethyl]oxan-4-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol
AHFS/Drugs.comInternational Drug Names
کد ATC
شناسه‌ها
  • β-D-glucopyranosyl-(1→6)-[β-D-glucopyranosyl-(1→3)-[β-D-glucopyranosyl-(1→6)]-β-D-glucopyranosyl-(1→3)-β-D-glucopyranosyl-(1→3)β-D-glucopyranosyl-(1→3)]-β-D-glucopyranose
شمارهٔ سی‌ای‌اس
پاب‌کم CID
کم‌اسپایدر
  • none
KEGG
CompTox Dashboard (EPA)
داده‌های فیزیکی و شیمیایی
فرمول شیمیاییC42H72O36
جرم مولی1152.99948 g/mol g·mol−1
 N✔Y (این چیست؟)  (صحت‌سنجی)

لنتینان (انگلیسی: Lentinan) یک پلی‌ساکارید است که از جسم بارده «شیتاکه» بدست می‌آید. (جلینه‌های لنتینولا اِدودِس)

وزن مولکولی این ماده، ۵۰۰٬۰۰۰ دالتون است و از سال ۱۹۸۵ میلادی به‌عنوان درمان اَدجوان سرطان معده در ژاپن بکار می‌رود.[۱] با آنکه پژوهش‌های بالینی محدودی بر روی بیماران سرطانی در ژاپن صورت پذیرفته‌است،[۲][۳][۴][۵][۶][۷][۸][۹] اما شواهد علمی کافی مبنی بر اثربخشی آن در درمان سرطان بدست نیامده است.[۱۰][۱۱]

عارضهٔ این ماده، «درماتیت قارچ شیتاکه» است.[۱۲]

منابع

  1. ↑ Smith JE; Rowan NJ; Sullivan R (2001). Medicinal Mushrooms: Their Therapeutic Properties and Current Medical Usage with Special Emphasis on Cancer Treatments. Cancer Research UK. {{cite book}}: Unknown parameter |nopp= ignored (|no-pp= suggested) (help)
  2. ↑ Yang P; Liang M; Zhang Y; Shen B (Aug 2008). "Clinical application of a combination therapy of lentinan, multi-electrode RFA and TACE in HCC". Advances in Therapy. 25 (8): 787–94. doi:10.1007/s12325-008-0079-x. PMID 18670743.
  3. ↑ Nimura H; Mitsumori N; Takahashi N; et al. (Jun 2006). "[S-1 combined with lentinan in patients with unresectable or recurrent gastric cancer]". Gan to Kagaku Ryoho (به ژاپنی). 33 (1): 106–9. PMID 16897983.
  4. ↑ Nakano H; Namatame K; Nemoto H; Motohashi H; Nishiyama K; Kumada K. (1999). "A multi-institutional prospective study of lentinan in advanced gastric cancer patients with unresectable and recurrent diseases: effect on prolongation of survival and improvement of quality of life. Kanagawa Lentinan Research Group". Hepatogastroenterology. 46 (28): 2662–8. PMID 10522061.
  5. ↑ Oba K, Kobayashi M, Matsui T, Kodera Y, Sakamoto J (July 2009). "Individual Patient Based Meta-analysis of Lentinan for Unresectable/Recurrent Gastric Cancer". Anticancer Research. 29 (7): 2739–45. PMID 19596954.
  6. ↑ Hazama S, Watanabe S, Ohashi M, et al. (July 2009). "Efficacy of Orally Administered Superfine Dispersed Lentinan (β-1,3-Glucan) for the Treatment of Advanced Colorectal Cancer". Anticancer Research. 29 (7): 2611–2617. PMID 19596936.
  7. ↑ Kataoka H, Shimura T, Mizoshita T, et al. (2009). "Lentinan with S-1 and paclitaxel for gastric cancer chemotherapy improve patient quality of life". Hepatogastroenterology. 56 (90): 547–50. PMID 19579640.
  8. ↑ Isoda N, Eguchi Y, Nukaya H, et al. (2009). "Clinical efficacy of superfine dispersed lentinan (β-1,3-glucan) in patients with hepatocellular carcinoma". Hepatogastroenterology. 56 (90): 437–41. PMID 19579616.
  9. ↑ Shimizu K, Watanabe S, Watanabe S, et al. (2009). "Efficacy of oral administered superfine dispersed lentinan for advanced pancreatic cancer". Hepatogastroenterology. 56 (89): 240–4. PMID 19453066.
  10. ↑ "Lentinan". WebMD. Retrieved June 10, 2017.
  11. ↑ "Lentinan". Memorial Sloan Kettering Cancer Center. Retrieved June 10, 2017.
  12. ↑ Nakamura, T (1992). "Shiitake (Lentinus edodes) dermatitis". Contact Dermatitis. 27 (2): 65–70. doi:10.1111/j.1600-0536.1992.tb05211.x. PMID 1395630.
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