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url url
  2. Weltenzyklopädie
  3. سنساوودین - ویکی‌پدیا، دانشنامهٔ آزاد
سنساوودین - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد
سنساوودین
داده‌های بالینی
نام‌های دیگر4'-ethynylstavudine, festinavir
وضعیت قانونی
وضعیت قانونی
  • Investigational
شناسه‌ها
  • 1-[(2R,5R)-5-ethynyl-5-(hydroxymethyl)-2H-furan-2-yl]-5-methylpyrimidine-2,4-dione
شمارهٔ سی‌ای‌اس
پاب‌کم CID
کم‌اسپایدر
UNII
KEGG
ChEMBL
NIAID ChemDB
CompTox Dashboard (EPA)
ECHA InfoCard100.225.812 ویرایش در ویکی‌داده
داده‌های فیزیکی و شیمیایی
فرمول شیمیاییC12H12N2O4
جرم مولی۲۴۸٫۲۳۸ g·mol−1
مدل سه بعدی (جی‌مول)
  • CC1=CN(C(=O)NC1=O)[C@H]2C=C[C@](O2)(CO)C#C
  • InChI=1S/C12H12N2O4/c1-3-12(7-15)5-4-9(18-12)14-6-8(2)10(16)13-11(14)17/h1,4-6,9,15H,7H2,2H3,(H,13,16,17)/t9-,12+/m1/s1
  • Key:OSYWBJSVKUFFSU-SKDRFNHKSA-N

سنساوودین (انگلیسی: Censavudine، پیش‌تر Festinavir)[۱] (INN)، (BMS-986001) یک داروی پژوهشی جدید است که توسط بریستول-مایرز اسکوئیب برای درمان عفونت HIV تولید شده است.[۲][۳] در آغاز در دانشگاه ییل توسعه داده شد.[۴]

منابع

  1. ↑ "International Nonproprietary Names for Pharmaceutical Substances (INN). Proposed International Nonproprietary Names: List 110" (PDF). World Health Organization. pp. 409–410.
  2. ↑ Wu VH, Smith RA, Masoum S, Raugi DN, Ba S, Seydi M, et al. (August 2017). "MK-8591 (4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine) Exhibits Potent Activity against HIV-2 Isolates and Drug-Resistant HIV-2 Mutants in Culture". Antimicrobial Agents and Chemotherapy. 61 (8). doi:10.1128/AAC.00744-17. PMC 5527656. PMID 28559249.
  3. ↑ Gupta SK, McComsey GA, Lombaard J, Echevarría J, Orrell C, Avihingsanon A, et al. (January 2016). "Efficacy, safety, bone and metabolic effects of HIV nucleoside reverse transcriptase inhibitor BMS-986001 (AI467003): a phase 2b randomised, controlled, partly blinded trial". The Lancet. HIV. 3 (1): e13-22. doi:10.1016/S2352-3018(15)00231-3. hdl:1805/10552. PMID 26762988.
  4. ↑ Alcorn, Keith (21 December 2010). "Bristol-Myers Squibb buys festinavir, new NRTI active against MDR HIV". aidsmap.com. aidsmap. Retrieved 24 June 2011.
آیکون خرد

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