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url url url url
  2. Weltenzyklopädie
  3. دومین FERM - ویکی‌پدیا، دانشنامهٔ آزاد
دومین FERM - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد
دومین ریشه آمینی FERM
ساختار کریستالی دومین FERM در مِرلین، پروتئین سرکوب‌گر تومور نوروفیبروماتوز ۲
شناسه‌ها
نمادFERM_N
پی‌فمPF09379
پی‌فم clanCL0072
اینترپروIPR018979
SCOPe1gc7 / SUPFAM
OPM superfamily49
OPM protein1gc6
Membranome161
دومین مرکزی FERM
ساختار کریستالی دومین متصل‌شونده به غشاء در پروتئین 4.1r
شناسه‌ها
نمادFERM_M
پی‌فمPF00373
اینترپروIPR019748
SCOPe1gc7 / SUPFAM
سی‌دی‌دیcd14473
ریشهٔ کربوکسیل FERM دومین شبه پی‌اچ
ساختار کریستالی دومین FERM در رادیکسین در ترکیب با انتهای سیتوپلاسمی NEP
شناسه‌ها
نمادFERM_C
پی‌فمPF09380
پی‌فم clanCL0266
اینترپروIPR018980
SCOPe1ef1 / SUPFAM
سی‌دی‌دیcd00836

دومِـین FERM (انگلیسی: FERM domain) یک واحد پروتئینی شایع است که کارش جانمایی و متمرکز نمودن پروتئین‌ها در غشای سلولی است.[۱] دومِـین‌های FERM در برخی پروتئین‌های مرتبط با اسکلت سلولی یافت می‌شود که کارشان اتصال به پروتئین‌های دیگر در مرز میان غشای سلولی و اسکلت سلولی است. دومِـین FERM در ریشهٔ آمینی پروتئین‌هایی است که این دومین را دارند.[۱][۲] توالی آمینواسیدی این دومین به‌شدت محافظت‌شده‌است.

از جمله پروتئین‌هایی که این دومین را دارند، می‌توان به تالین، تیروزین کیناز ۲ غیرگیرنده‌ای، جانوس کیناز، کیناز چسبندگی موضعی، میوزین‌های ۱۰، ۷ و ۱۵، پروتئین بیتی، فیلوپودین و پروتئین تیروزین فسفاتاز اشاره کرد.

منابع

  1. ↑ ۱٫۰ ۱٫۱ Chishti AH, Kim AC, Marfatia SM, Lutchman M, Hanspal M, Jindal H, Liu SC, Low PS, Rouleau GA, Mohandas N, Chasis JA, Conboy JG, Gascard P, Takakuwa Y, Huang SC, Benz EJ, Bretscher A, Fehon RG, Gusella JF, Ramesh V, Solomon F, Marchesi VT, Tsukita S, Tsukita S, Hoover KB (August 1998). "The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane". Trends Biochem. Sci. 23 (8): 281–2. doi:10.1016/S0968-0004(98)01237-7. PMID 9757824.
  2. ↑ Pearson MA, Reczek D, Bretscher A, Karplus PA (April 2000). "Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain". Cell. 101 (3): 259–70. doi:10.1016/S0092-8674(00)80836-3. PMID 10847681. S2CID 7119092.
آیکون خرد

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