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  1. Weltenzyklopädie
  2. درلین-۲ - ویکی‌پدیا، دانشنامهٔ آزاد
درلین-۲ - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد
DERL2
معین‌کننده‌ها
نام‌های دیگرDERL2, F-LAN-1, F-LANa, FLANa, CGI-101, DERtrin-2, derlin 2, derlin-2
شناسه‌های بیرونیOMIM: 610304 MGI: 2151483 HomoloGene: 9356 GeneCards: DERL2
موقعیت ژن (موش)
کروموزوم ۱۱ (موش)
کروموزومکروموزوم ۱۱ (موش)[۱]
کروموزوم ۱۱ (موش)
موقعیت ژنومی DERL2
موقعیت ژنومی DERL2
نوار11 B4|11 43.21 cMشروع70,897,990 bp[۱]
پایان70,910,667 bp[۱]
الگوی گسترش RNA
More reference expression data
هستی‌شناسی ژن
عملکرد ملکولی• GO:0001948، GO:0016582 پیوند پروتئینی
• serine-type endopeptidase activity
ترکیبات سلولی• integral component of membrane
• integral component of endoplasmic reticulum membrane
• late endosome
• early endosome
• endoplasmic reticulum membrane
• شبکه آندوپلاسمی
• membrane
• endoplasmic reticulum quality control compartment
• signal recognition particle receptor complex
• ذره شناسایی سیگنال
فرایند زیستی• endoplasmic reticulum unfolded protein response
• positive regulation of cell growth
• retrograde protein transport, ER to cytosol
• response to unfolded protein
• negative regulation of retrograde protein transport, ER to cytosol
• positive regulation of cell population proliferation
• ubiquitin-dependent ERAD pathway
• suckling behavior
• endoplasmic reticulum mannose trimming
• پروتئین‌کافت
منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌هاانسانموش
Entrez

51009

116891

آنسامبل

ENSG00000072849

ENSMUSG00000018442

یونی‌پروت

Q9GZP9

Q8BNI4

RefSeq (mRNA)

NM_001304779، NM_016041، NR_130905، NR_130906، XR_001752523، XR_002958015، XR_002958016 NM_001304777، NM_001304779، NM_016041، NR_130905، NR_130906، XR_001752523، XR_002958015، XR_002958016

NM_001291147، NM_001291148، NM_033562، XM_017314227 NM_001291146، NM_001291147، NM_001291148، NM_033562، XM_017314227

RefSeq (پروتئین)

NP_001291708، NP_057125 NP_001291706، NP_001291708، NP_057125

NP_001278076، NP_001278077، NP_291040، XP_017169716 NP_001278075، NP_001278076، NP_001278077، NP_291040، XP_017169716

موقعیت (UCSC)ن/مChr : 70.9 – 70.91 Mb
جستجوی PubMed[۲][۳]
ویکی‌داده
مشاهده/ویرایش انسانمشاهده/ویرایش موش

درلین-۲ پروتئینی است که در انسان توسط ژن DERL2 کدگذاری می‌شود.[۴][۵][۶]

همچنین ببینید

[ویرایش]
  • Derlin-1
  • Derlin-3

منابع

[ویرایش]
  1. ↑ ۱٫۰ ۱٫۱ ۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000018442 - Ensembl, May 2017
  2. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (Aug 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
  5. ↑ Ying H, Yu Y, Xu Y (Aug 2001). "Cloning and characterization of F-LANa, upregulated in human liver cancer". Biochem Biophys Res Commun. 286 (2): 394–400. doi:10.1006/bbrc.2001.5390. PMID 11500051.
  6. ↑ "Entrez Gene: DERL2 Der1-like domain family, member 2".

جهت مطالعه

[ویرایش]
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Lilley BN, Ploegh HL (2004). "A membrane protein required for dislocation of misfolded proteins from the ER". Nature. 429 (6994): 834–40. Bibcode:2004Natur.429..834L. doi:10.1038/nature02592. PMID 15215855. S2CID 29483256.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Lilley BN, Ploegh HL (2006). "Multiprotein complexes that link dislocation, ubiquitination, and extraction of misfolded proteins from the endoplasmic reticulum membrane". Proc. Natl. Acad. Sci. U.S.A. 102 (40): 14296–301. doi:10.1073/pnas.0505014102. PMC 1242303. PMID 16186509.
  • Oda Y, Okada T, Yoshida H, et al. (2006). "Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation". J. Cell Biol. 172 (3): 383–93. doi:10.1083/jcb.200507057. PMC 2063648. PMID 16449189.
  • Rhee S, Grinnell F (2006). "P21-activated kinase 1: convergence point in PDGF- and LPA-stimulated collagen matrix contraction by human fibroblasts". J. Cell Biol. 172 (3): 423–32. doi:10.1083/jcb.200505175. PMC 2063651. PMID 16449192.
  • Maas C, Tagnaouti N, Loebrich S, et al. (2006). "Neuronal cotransport of glycine receptor and the scaffold protein gephyrin". J. Cell Biol. 172 (3): 441–51. doi:10.1083/jcb.200506066. PMC 2063653. PMID 16449194.
  • Lilley BN, Gilbert JM, Ploegh HL, Benjamin TL (2006). "Murine polyomavirus requires the endoplasmic reticulum protein Derlin-2 to initiate infection". J. Virol. 80 (17): 8739–44. doi:10.1128/JVI.00791-06. PMC 1563856. PMID 16912321.
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