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S1 Informatics S1 Information Systems S1 Information Technology S1 Computer Engineering S1 Electrical Engineering S1 Civil Engineering

faculty of Economics and Business
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Faculty of Letters and Educational Sciences
S1 English literature S1 English language education S1 Mathematics education S1 Sports Education
teknopedia

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url url
  2. Weltenzyklopädie
  3. تروپیفکسور - ویکی‌پدیا، دانشنامهٔ آزاد
تروپیفکسور - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد
تروپیفکسور
داده‌های بالینی
کد ATC
  • None
شناسه‌ها
  • 2-[(1R,5S)-3-[[5-Cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl]methoxy]-8-azabicyclo[3.2.1]octan-8-yl]-4-fluoro-1,3-benzothiazole-6-carboxylic acid
شمارهٔ سی‌ای‌اس
پاب‌کم CID
UNII
KEGG
داده‌های فیزیکی و شیمیایی
فرمول شیمیاییC۲۹H۲۵F۴N۳O۵S۱
جرم مولی۶۰۳٫۵۹ g·mol−1
مدل سه بعدی (جی‌مول)
  • C1C[C@H]2CC(C[C@@H]1N2C3=NC4=C(C=C(C=C4S3)C(=O)O)F)OCC5=C(ON=C5C6=CC=CC=C6OC(F)(F)F)C7CC7
  • InChI=1S/C29H25F4N3O5S/c30-21-9-15(27(37)38)10-23-25(21)34-28(42-23)36-16-7-8-17(36)12-18(11-16)39-13-20-24(35-41-26(20)14-5-6-14)19-3-1-2-4-22(19)40-29(31,32)33/h1-4,9-10,14,16-18H,5-8,11-13H2,(H,37,38)/t16-,۱۷+,۱۸+
  • Key:VYLOOGHLKSNNEK-PIIMJCKOSA-N

تروپیفکسور (انگلیسی: Tropifexor) یک داروی پژوهشی است که به عنوان آگونیست گیرنده X فارنسوئید (FXR) عمل می‌کند.[۱] این دارو برای درمان بیماری‌های کبدی کلستاتیک و استئاتوهپاتیت غیر الکلی (NASH) و فیبروز کبدی ساخته شد..[۲]

منابع

  1. ↑ Tully DC, Rucker PV, Chianelli D, Williams J, Vidal A, Alper PB, et al. (December 2017). "Discovery of Tropifexor (LJN452), a Highly Potent Non-bile Acid FXR Agonist for the Treatment of Cholestatic Liver Diseases and Nonalcoholic Steatohepatitis (NASH)". Journal of Medicinal Chemistry. 60 (24): 9960–9973. doi:10.1021/acs.jmedchem.7b00907. PMID 29148806.
  2. ↑ ClinicalTrials.gov NCT03517540 Safety, Tolerability, and Efficacy of a Combination Treatment of Tropifexor (LJN452) and Cenicriviroc (CVC) in Adult Patients With Nonalcoholic Steatohepatitis (NASH) and Liver Fibrosis. (TANDEM)
آیکون خرد

این یک مقالهٔ خرد داروشناسی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

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