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faculty of Economics and Business
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url url
  2. Weltenzyklopädie
  3. آبارلیکس - ویکی‌پدیا، دانشنامهٔ آزاد
آبارلیکس - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد
آبارلیکس
داده‌های بالینی
نام‌های تجاریPlenaxis
AHFS/Drugs.commonograph
روش مصرف داروتزریق عضلانی
گروه داروییGnRH analogue; GnRH antagonist; Antigonadotropin
کد ATC
داده‌های فارماکوکینتیک
پیوند پروتئینی96–99%
شناسه‌ها
  • N-acetyl-3-(2-naphthyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridyl)-D-alanyl-L-seryl-N-methyl-L-tyrosyl-D-asparagyl-L-leucyl-N6-isopropyl-L-lysyl-L-prolyl-D-alaninamide[۱]
شمارهٔ سی‌ای‌اس
پاب‌کم CID
IUPHAR/BPS
دراگ‌بنک
کم‌اسپایدر
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
داده‌های فیزیکی و شیمیایی
فرمول شیمیاییC72H95ClN14O14
جرم مولی۱۴۱۶٫۰۹ g·mol−1
مدل سه بعدی (جی‌مول)
  • CC(C)C[C@H](NC(=O)[C@@H](CC(N)=O)NC(=O)[C@H](Cc1ccc(O)cc1)N(C)C(=O)[C@H](CO)NC(=O)[C@@H](Cc2cccnc2)NC(=O)[C@@H](Cc3ccc(Cl)cc3)NC(=O)[C@@H](NCc5ccc4ccccc4c5)NC(C)=O)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N6CCC[C@H]6C(=O)N[C@H](C)C(N)=O
  • InChI=1S/C72H95ClN14O14/c1-41(2)32-54(64(93)80-53(17-10-11-30-77-42(3)4)72(101)87-31-13-18-60(87)69(98)78-43(5)63(75)92)81-68(97)58(38-62(74)91)84-70(99)61(37-46-22-27-52(90)28-23-46)86(7)71(100)59(40-88)85-67(96)57(36-48-14-12-29-76-39-48)83-66(95)56(34-45-20-25-51(73)26-21-45)82-65(94)55(79-44(6)89)35-47-19-24-49-15-8-9-16-50(49)33-47/h8-9,12,14-16,19-29,33,39,41-43,53-61,77,88,90H,10-11,13,17-18,30-32,34-38,40H2,1-7H3,(H2,74,91)(H2,75,92)(H,78,98)(H,79,89)(H,80,93)(H,81,97)(H,82,94)(H,83,95)(H,84,99)(H,85,96)/t43-,53+,54+,55-,56-,57-,58-,59+,60+,61+/m1/s1 ✔Y
  • Key:AIWRTTMUVOZGPW-HSPKUQOVSA-N ✔Y
 N✔Y (این چیست؟)  (صحت‌سنجی)

آبارلیکس (انگلیسی: Abarelix) یک آنتاگونیست هورمون آزادکننده گنادوتروپین تزریقی (آنتاگونیست GnRH) است که در آلمان و هلند به بازار عرضه می شود. این دارو عمدتاً در انکولوژی برای کاهش میزان تستوسترون ساخته شده در بیماران مبتلا به سرطان پروستات علامت‌دار پیشرفته که هیچ گزینه درمانی دیگری برای آن در دسترس نیست استفاده می‌شود.[۲][۳]

منابع

  1. ↑ "Abarelix". PubChem. 2017-07-29.
  2. ↑ "Abarelix". Drugs.com. Archived from the original on 10 February 2018. Retrieved 22 July 2023.
  3. ↑ Boccon-Gibod L, van der Meulen E, Persson BE (June 2011). "An update on the use of gonadotropin-releasing hormone antagonists in prostate cancer". Therapeutic Advances in Urology. 3 (3): 127–40. doi:10.1177/1756287211414457. PMC 3159401. PMID 21904569.
آیکون خرد

این یک مقالهٔ خرد داروشناسی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

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