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url url url url
  2. Weltenzyklopädie
  3. گیرنده‌های اوپیوئید - ویکی‌پدیا، دانشنامهٔ آزاد
گیرنده‌های اوپیوئید - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد
پویانمایی از گیرنده اوپیوئید k در انسان که به وسیله آنتاگونیست JDTic مسدود شده.

آگونیست‌های اوپیوئید، بی دردی را با اتصال به گیرنده‌های اختصاصی جفت شده با پروتئین G تولید می‌کنند. سه گونه اصلی از گیرنده‌های اوپیوئید عبارتند از: μ، δ و κ. هر گونه از گیرنده‌های اوپیوئید، خود زیر گونه‌هایی دارد؛ μ1، μ2، δ1، δ2، κ1، κ2، κ3 زیر گونه‌هایی هستند که در حال حاضر با معیارهای فارماکولوژیک، به خوبی تأیید می‌شوند. اخیراً یک سیستم جدید لیگاند – گیرنده اوپیوئید تحت عنوان N/OFQ کشف شده‌است؛ گیرنده اصلی در این سیستم، اورفانین شبه اوپیوئید – زیرگروه ۱ (به انگلیسی: orphanin opioid-receptor-like subtype 1) (به اختصار ORL1) جفت شونده با پروتئین G می‌باشد. لیگاند درونزاد این گیرنده با نام‌های اورفانین FQ و همچنین Nociceptin نامگذاری شده‌است.

در سال ۲۰۰۰، اتحادیه بین‌المللی داروشناسی، عبارات MOP, DOP, KOP و NOP را به ترتیب برای نام‌گذاری گیرنده‌های μ، δ، κ و N/OFQ به تصویب رساند.

جستارهای وابسته

منابع

  • صوفی، حامد (۱۳۹۱)، بررسی الگوی مصرف داروهای مخدر تزریقی در بیمارستان امیرالمؤمنین شهرستان زابل، پایان‌نامه دکتری عمومی داروسازی، دانشگاه علوم پزشکی شهید بهشتی، شماره ۱۱۲۸، صفحهٔ ۵۱.
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