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url url url url
  2. Weltenzyklopädie
  3. کاسوپیتانت - ویکی‌پدیا، دانشنامهٔ آزاد
کاسوپیتانت - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد
کاسوپیتانت
داده‌های بالینی
نام‌های دیگرGW679769; GW-679769; (2R,4S)-4-(4-Acetylpiperazin-1-yl)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methylpiperidine-1-carboxamide
کد ATC
شناسه‌ها
  • (2S,4S)-4-(4-Acetyl-1-piperazinyl)-N-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl]-2-(4-fluoro-2-methylphenyl)-N-methyl-1-piperidinecarboxamide
شمارهٔ سی‌ای‌اس
پاب‌کم CID
کم‌اسپایدر
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
داده‌های فیزیکی و شیمیایی
فرمول شیمیاییC30H35F7N4O2
جرم مولی۶۱۶٫۶۲۵ g·mol−1
مدل سه بعدی (جی‌مول)
  • CC1=C(C=CC(=C1)F)[C@@H]2C[C@H](CCN2C(=O)N(C)[C@H](C)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)N4CCN(CC4)C(=O)C
  • InChI=1S/C30H35F7N4O2/c1-18-13-24(31)5-6-26(18)27-17-25(40-11-9-39(10-12-40)20(3)42)7-8-41(27)28(43)38(4)19(2)21-14-22(29(32,33)34)16-23(15-21)30(35,36)37/h5-6,13-16,19,25,27H,7-12,17H2,1-4H3/t19-,25-,27+/m1/s1
  • Key:XGGTZCKQRWXCHW-JRLVAEJTSA-N
  (صحت‌سنجی)

کاسوپیتانت (انگلیسی: Casopitant) یک آنتاگونیست گیرنده NK1 است[۱] که تحت تحقیق برای درمان تهوع و استفراغ ناشی از شیمی درمانی بود.[۲][۳] یک بررسی در سال ۲۰۲۲، کاسوپیتانت را به‌عنوان یک داروی ضد افسردگی جدید بالقوه برای درمان اختلال افسردگی اساسی، با تکمیل فاز ۲ کارآزمایی بالینی، فهرست کرد.[۴]

منابع

  1. ↑ "International Nonproprietary Names for Pharmaceutical Substances (INN). Recommended International Nonproprietary Names: List56" (PDF). World Health Organization. 2006. Retrieved 17 November 2016.
  2. ↑ Name, Drug (25 December 2021). "Casopitant". AdisInsight. Retrieved 21 August 2022.
  3. ↑ Lohr L (2008). "Chemotherapy-induced nausea and vomiting". Cancer Journal. 14 (2): 85–93. doi:10.1097/PPO.0b013e31816a0f07. PMID 18391612. S2CID 43224257.
  4. ↑ Sakurai H, Yonezawa K, Tani H, Mimura M, Bauer M, Uchida H (July 2022). "Novel Antidepressants in the Pipeline (Phase II and III): A Systematic Review of the US Clinical Trials Registry". Pharmacopsychiatry. 55 (4): 193–202. doi:10.1055/a-1714-9097. PMC 9259184. PMID 35045580.

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