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url url url url
  2. Weltenzyklopädie
  3. بوکولوم - ویکی‌پدیا، دانشنامهٔ آزاد
بوکولوم - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد
بوکولوم
داده‌های بالینی
نام‌های دیگرBucolome, Paramidine
AHFS/Drugs.comInternational Drug Names
کد ATC
  • None
شناسه‌ها
  • 5-butyl-1-cyclohexyl-1,3-diazinane-2,4,6-trione
شمارهٔ سی‌ای‌اس
پاب‌کم CID
کم‌اسپایدر
UNII
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.011.515 ویرایش در ویکی‌داده
داده‌های فیزیکی و شیمیایی
فرمول شیمیاییC14H22N2O3
جرم مولی۲۶۶٫۳۴۱ g·mol−1
مدل سه بعدی (جی‌مول)
  • CCCCC1C(=O)NC(=O)N(C1=O)C2CCCCC2
  • InChI=1S/C14H22N2O3/c1-2-3-9-11-12(17)15-14(19)16(13(11)18)10-7-5-4-6-8-10/h10-11H,2-9H2,1H3,(H,15,17,19) ✔Y
  • Key:DVEQCIBLXRSYPH-UHFFFAOYSA-N ✔Y
  (صحت‌سنجی)

بوکولوم (انگلیسی: Bucolome) یک مشتق باربیتورات است که برخلاف بسیاری از باربیتورات ها، هیچ اثر آرام بخش یا خواب آور قابل توجهی ندارد، اما در عوض به عنوان یک مسکن و ضد التهاب عمل می‌کند. همچنین به عنوان یک مهارکننده CYP2C9 عمل می‌کند و متابولیسم چندین داروی رایج را کاهش می‌دهد، که آن را برای تقویت یا افزایش مدت اثر آن داروها یا کاهش تولید متابولیت‌های ناخواسته سودمند می‌کند.[۱][۲][۳]

منابع

  1. ↑ Takamura N, Maruyama T, Chosa E, Kawai K, Tsutsumi Y, Uryu Y, et al. (April 2005). "Bucolome, a potent binding inhibitor for furosemide, alters the pharmacokinetics and diuretic effect of furosemide: potential for use of bucolome to restore diuretic response in nephrotic syndrome". Drug Metabolism and Disposition. 33 (4): 596–602. CiteSeerX 10.1.1.658.6194. doi:10.1124/dmd.104.002782. PMID 15640375. S2CID 1184330.
  2. ↑ Osawa M, Hada N, Matsumoto K, Hasegawa T, Kobayashi D, Morimoto Y, et al. (April 2005). "Usefulness of coadministration of bucolome in warfarin therapy: pharmacokinetic and pharmacodynamic analysis using outpatient prescriptions". International Journal of Pharmaceutics. 293 (1–2): 43–9. doi:10.1016/j.ijpharm.2004.12.009. PMID 15778043.
  3. ↑ Kobayashi M, Takagi M, Fukumoto K, Kato R, Tanaka K, Ueno K (2008). "The effect of bucolome, a CYP2C9 inhibitor, on the pharmacokinetics of losartan". Drug Metabolism and Pharmacokinetics. 23 (2): 115–9. doi:10.2133/dmpk.23.115. PMID 18445991.
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