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url url url url
  2. Weltenzyklopädie
  3. برودالومب - ویکی‌پدیا، دانشنامهٔ آزاد
برودالومب - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد
برودالومب
پادتن مونوکلونال
گونهWhole antibody
منبعانسان
هدفInterleukin 17 receptor A
داده‌های بالینی
نام‌های تجاریSiliq, Kyntheum, Lumicef
نام‌های دیگرKHK4827, AMG 827
داده‌ها
کد ATC
وضعیت قانونی
وضعیت قانونی
شناسه‌ها
شمارهٔ سی‌ای‌اس
دراگ‌بنک
کم‌اسپایدر
  • none
UNII
KEGG
داده‌های فیزیکی و شیمیایی
فرمول شیمیاییC6372H9840N1712O1988S52
جرم مولی۱۴۳۹۰۵٫۹۳ g·mol−1
 N✔Y (این چیست؟)  (صحت‌سنجی)

برودالومب (انگلیسی: Brodalumab) یک آنتی‌بادی مونوکلونال انسانی است که برای درمان بیماری های التهابی ساخته شده است.[۴]

در فوریه ۲۰۱۷، تأییدیه FDA ایالات متحده را برای درمان پسوریازیس پلاکی متوسط ​​تا شدید در افرادی که با سایر درمان‌ها بهبود نیافته‌اند، دریافت کرد.[۵]

مکانیسم عمل

برودالومب به گیرنده اینترلوکین ۱۷ متصل می‌شود و بنابراین از فعال شدن گیرنده اینترلوکین ۱۷ (IL-17) جلوگیری می‌کند. این فرایند شبیه به آنتی‌بادی ضد پسوریازیس دیگر، ایکسیکیزوماب است که با این حال به خود IL-17 متصل می‌شود.

منابع

  1. ↑ "Search Page - Drug and Health Product Register". 23 October 2014. Archived from the original on 2022-06-07. Retrieved 2022-06-10.
  2. ↑ "Siliq- brodalumab injection". DailyMed. 12 June 2020. Archived from the original on 18 March 2021. Retrieved 8 June 2022.
  3. ↑ "Kyntheum EPAR". European Medicines Agency. 17 September 2018. Archived from the original on 13 September 2021. Retrieved 8 June 2022.
  4. ↑ "Statement On A Nonproprietary Name Adopted By The USAN Council: Brodalumab" (PDF). American Medical Association. Archived (PDF) from the original on 2016-02-01. Retrieved 2011-09-08.
  5. ↑ "FDA approves new psoriasis drug" (Press release). U.S. Food and Drug Administration. 15 February 2017. Archived from the original on 11 December 2019. Retrieved 18 February 2017.
آیکون خرد

این یک مقالهٔ خرد داروشناسی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

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