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url url
  2. Weltenzyklopädie
  3. اراواسایکلین - ویکی‌پدیا، دانشنامهٔ آزاد
اراواسایکلین - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد
اراواسایکلین
نام‌گذاری آیوپاک

(4S4aS5aR12aS)-4-(Dimethylamino)-7-fluoro-3101212a-tetrahydroxy-111-dioxo-9-[(1-pyrrolidinylacetyl)amino]-144a55a61112a-octahydro-2-tetracenecarboxamide

دیگر نام‌ها

Xerava

شناساگرها
شماره ثبت سی‌ای‌اس ۱۲۰۷۲۸۳-۸۵-۹
پاب‌کم ۵۴۷۲۶۱۹۲
کم‌اسپایدر ۲۸۴۹۵۴۸۵
KEGG D10421
جی‌مول-تصاویر سه بعدی Image 1

  • CN(C)[C@H]1[C@@H]2C[C@@H]3CC4=C(C=C(C(=C4C(=O)C3=C([C@@]2(C(=O)C(=C1O)C(=O)N)O)O)O)NC(=O)CN5CCCC5)F

  • InChI=1S/C27H31FN4O8/c1-31(2)20-13-8-11-7-12-14(28)9-15(30-16(33)10-32-5-3-4-6-32)21(34)18(12)22(35)17(11)24(37)27(13,40)25(38)19(23(20)36)26(29)39/h9,11,13,20,34,36-37,40H,3-8,10H2,1-2H3,(H2,29,39)(H,30,33)/t11-,13-,20-,27-/m0/s1
    Key: HLFSMUUOKPBTSM-ISIOAQNYSA-N

خصوصیات
فرمول مولکولی C27H31FN4O8
جرم مولی 558.555
به استثنای جایی که اشاره شده‌است در غیر این صورت، داده‌ها برای مواد به وضعیت استانداردشان داده شده‌اند (در 25 °C (۷۷ °F)، ۱۰۰ kPa)
Infobox references

اراواسایکلین(به انگلیسی: Eravacycline) (TP-434 ،Xerava) یک آنتی‌بیوتیک از دسته تتراسایکلین هالوژنه‌شده صناعی است.

کاربردهای پزشکی

اراواسایکلین طیف گسترده‌ای از فعالیت را در برابر انواع باکتری‌های گرم مثبت و گرم منفی، از جمله سویه‌های مقاوم به درمان، مانند استافیلوکوک اورئوس مقاوم به متی سیلین (MRSA) و انتروباکتریاسیا مقاوم به کارباپنم از خود نشان داده است.[۱] این دارو در حال حاضر برای تجویز داخل وریدی و خوراکی فرموله می‌شود.

طیف فعالیت [۱] [۲] [۳] [۴]

باکتری‌های گرم-مثبت

باکتری‌های گرم-منفی

منابع

  1. ↑ ۱٫۰ ۱٫۱ Zhanel, George G.; Cheung, Doris; Adam, Heather; Zelenitsky, Sheryl; Golden, Alyssa; Schweizer, Frank; Gorityala, Bala; Lagacé-Wiens, Philippe R. S.; Walkty, Andrew (2016-04-01). "Review of Eravacycline, a Novel Fluorocycline Antibacterial Agent". Drugs. 76 (5): 567–588. doi:10.1007/s40265-016-0545-8. ISSN 1179-1950. PMID 26863149.
  2. ↑ Sutcliffe, J. A.; O'Brien, W.; Fyfe, C.; Grossman, T. H. (2013-11-01). "Antibacterial activity of eravacycline (TP-434), a novel fluorocycline, against hospital and community pathogens". Antimicrobial Agents and Chemotherapy. 57 (11): 5548–5558. doi:10.1128/AAC.01288-13. ISSN 1098-6596. PMC 3811277. PMID 23979750.
  3. ↑ Solomkin, Joseph S.; Ramesh, Mayakonda Krishnamurthy; Cesnauskas, Gintaras; Novikovs, Nikolajs; Stefanova, Penka; Sutcliffe, Joyce A.; Walpole, Susannah M.; Horn, Patrick T. (2014-01-01). "Phase 2, randomized, double-blind study of the efficacy and safety of two dose regimens of eravacycline versus ertapenem for adult community-acquired complicated intra-abdominal infections". Antimicrobial Agents and Chemotherapy. 58 (4): 1847–1854. doi:10.1128/AAC.01614-13. ISSN 1098-6596. PMC 4023720. PMID 24342651.
  4. ↑ Abdallah, Marie; Olafisoye, Olawole; Cortes, Christopher; Urban, Carl; Landman, David; Quale, John (2015-03-01). "Activity of eravacycline against Enterobacteriaceae and Acinetobacter baumannii, including multidrug-resistant isolates, from New York City". Antimicrobial Agents and Chemotherapy. 59 (3): 1802–1805. doi:10.1128/AAC.04809-14. ISSN 1098-6596. PMC 4325809. PMID 25534744.

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