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url url url url
  2. Weltenzyklopädie
  3. آیوبنگوان - ویکی‌پدیا، دانشنامهٔ آزاد
آیوبنگوان - ویکی‌پدیا، دانشنامهٔ آزاد
از ویکی‌پدیا، دانشنامهٔ آزاد
آیوبنگوان
داده‌های بالینی
نام‌های تجاریآدرویو, آزدرا
نام‌های دیگرmeta-iodobenzylguanidine
mIBG, MIBG
داده‌ها
روش مصرف داروتزریق وریدی
کد ATC
وضعیت قانونی
وضعیت قانونی
شناسه‌ها
  • 1-(3-iodobenzyl)guanidine
شمارهٔ سی‌ای‌اس
پاب‌کم CID
دراگ‌بنک
کم‌اسپایدر
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
داده‌های فیزیکی و شیمیایی
فرمول شیمیاییC۸H۱۰I۱N۳
جرم مولی۲۷۵٫۰۹۳ g·mol−1
مدل سه بعدی (جی‌مول)
  • C1=CC(=CC(=C1)I)CNC(=N)N
  • InChI=1S/C8H10IN3/c9-7-3-1-2-6(4-7)5-12-8(10)11/h1-4H,5H2,(H4,۱۰٬۱۱٬۱۲) N
  • Key:PDWUPXJEEYOOTR-UHFFFAOYSA-N N
 N✔Y (این چیست؟)  (صحت‌سنجی)

آیوبنگوان (انگلیسی: Iobenguane) داروی آنالوگ نوراپی‌نفرین است که معمولاً به عنوان یک رادیودارو از آن استفاده می‌شود[۳] و به عنوان یک عامل مسدودکننده برای نورون‌های آدرنرژیک عمل می‌کند. هنگامی که نشاندار می‌شود، می‌تواند در تکنیک‌های تشخیصی و درمانی پزشکی هسته‌ای و همچنین در درمان‌های شیمی‌درمانی تومورهای نورواندوکرین مورد استفاده واقع شود.

این دارو در بافت آدرنرژیک تجمع می‌یابد و بنابراین می‌تواند برای شناسایی محل تومورهایی مانند فئوکروموسیتوما، پاراگانگلیوما و نوروبلاستوما استفاده شود.[۴] آیوبنگوان به همراه ید-۱۳۱ می‌تواند برای درمان سلول‌های توموری که نوراپی‌نفرین را جذب و متابولیزه می‌کنند نیز استفاده کرد.

عوارض جانبی این دارو نادر است اما ممکن است باعث تپش قلب، رنگ‌پریدگی، استفراغ و درد شکمی شود.[۵]

منابع

  1. ↑ "Adreview- iobenguane i-123 injection". DailyMed. 10 March 2020. Retrieved 21 May 2022.
  2. ↑ "Azedra- iobenguane i-131 injection, solution". DailyMed. 8 April 2021. Retrieved 21 May 2022.
  3. ↑ Olecki E, Grant CN (December 2019). "MIBG in neuroblastoma diagnosis and treatment". Seminars in Pediatric Surgery. 28 (6): 150859. doi:10.1016/j.sempedsurg.2019.150859. PMID 31931960. S2CID 210191760.
  4. ↑ Scarsbrook AF, Ganeshan A, Statham J, Thakker RV, Weaver A, Talbot D, et al. (2007). "Anatomic and functional imaging of metastatic carcinoid tumors". Radiographics. 27 (2): 455–477. doi:10.1148/rg.272065058. PMID 17374863.
  5. ↑ Taïeb D, Hicks RJ, Hindié E, Guillet BA, Avram A, Ghedini P, et al. (September 2019). "European Association of Nuclear Medicine Practice Guideline/Society of Nuclear Medicine and Molecular Imaging Procedure Standard 2019 for radionuclide imaging of phaeochromocytoma and paraganglioma". European Journal of Nuclear Medicine and Molecular Imaging. 46 (10): 2112–2137. doi:10.1007/s00259-019-04398-1. PMC 7446938. PMID 31254038.
آیکون خرد

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