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url url url url
  2. Weltenzyklopädie
  3. آلفا یک آنتی‌کیموتریپسین - ویکی‌پدیا، دانشنامهٔ آزاد
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از ویکی‌پدیا، دانشنامهٔ آزاد

آلفا یک آنتی‌کیموتریپسین (انگلیسی: Alpha 1-antichymotrypsin) یک گلیکوپروتئین از گروه آلفاگلوبولین‌ها و از خانواده سرپین است. این پروتئین فعالیت برخی پروتئازها مانند کاتپسین G (یکی از آنزیم‌های نوتروفیل‌ها) را مهار می‌کند. سرپین‌ها گروه مختلفی از پروتئین‌ها هستند که آنزیم سرین پروتئاز را مهار می‌کنند.

این پروتئین در کبد تولید می‌شود و یکی از پروتئین‌های فاز حاد است.

اهمیت بالینی

کمبود این پروتئین با بیماری کبد مرتبط است. جهش هایی در بیماران مبتلا به بیماری پارکینسون و بیماری مزمن انسدادی ریه شناسایی شده است. آلفا 1-آنتی کیموتریپسین همچنین با بیماری زایی بیمای آلزایمر مرتبط است، زیرا باعث افزایش تشکیل فیبرهای آمیلوئید در این بیماری می شود.

همکاری ها

نشان داده شده است که آلفا 1-آنتی کیموتریپسین با DNAJC1 تعامل پروتئین-پروتئین دارد.

جستارهای وابسته

منابع

آیکون خرد

این یک مقالهٔ خرد پزشکی است. می‌توانید با گسترش آن به ویکی‌پدیا کمک کنید.

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